Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer

Kumar Utkarsh; Abhishek Kumar; Aditi; Azhar Khan; Ashima Nayyar; Shabirul Haque; Shams Iqbal

doi:10.1016/j.gendis.2022.07.004

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Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer

Review article | 更新时间：2023-08-29

- Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Tisch Cancer Institute, Icahn School of Medicine, Mt. Sinai,NY,USA,10029
  2. Department of Microbiology and Biotechnology, Shoolini University, Solan, Himachal Pradesh,India,173229
  3. Department of Autoimmune Diseases, Feinstein Institute for Medical Research, Northwell Health, Manhasset,NY,USA,11030
  4. Vascular Interventional Radiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School,MA,Boston,USA,02115
  5. Faculty of Applied Science and Biotechnology, Shoolini University, Solan, Himachal Pradesh,India,173229
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.07.004
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
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Kumar Utkarsh, Abhishek Kumar, Aditi, et al. Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer. [J]. Genes & Diseases 10(3).(2023)
DOI：

Kumar Utkarsh, Abhishek Kumar, Aditi, et al. Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2022.07.004.

摘要

Abstract

Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However

the study of such biomarkers at nanovesicle technology such as exosomes

proteomic and genomics studies could further contribute to better identification of anomalous protein and networks which could act as potential targets for biomarker and immunotherapy development. This review provides an overview of the circulating and non-circulating biomarkers with the aim of addressing the current challenges and potential biomarkers that could lead to early ovarian cancer diagnosis and better management. By means of this review we also lay a hypothesis that characterization of exosomal protein

nucleic acid content from body fluids (serum

plasma

urine

etc.) can decode the secret of disease and potentially improve diagnostic sensitivity which could further lead to more effective screening and early detection of the disease.

关键词

Keywords

BiomarkerCirculating proteinExosomesExtracellular vesiclesOvarian cancerProteomics

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