Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes

Hong-Yang Luo; Jie-Ying Zhu; Min Chen; Wang-Jing Mu; Liang Guo

doi:10.1016/j.gendis.2022.06.005

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Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes

Review article | 更新时间：2023-08-29

- Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport,Shanghai,China,200438
  2. School of Kinesiology, Shanghai University of Sport,Shanghai,China,200438
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.06.005
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
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Hong-Yang Luo, Jie-Ying Zhu, Min Chen, et al. Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes. [J]. Genes & Diseases 10(3).(2023)
DOI：

Hong-Yang Luo, Jie-Ying Zhu, Min Chen, et al. Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2022.06.005.

摘要

Abstract

Krüppel-like factor 10 (KLF10)

also known as TGFβ-inducible early gene-1 (TIEG1)

was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research

KLF10 has been found to have complex functions in many different cell types

and its expression and function is regulated in multiple ways. As a downstream factor of transforming growth factor β (TGFβ)/SMAD signaling

KLF10 is involved in various biological functions

including glucose and lipid metabolism in liver and adipose tissue

the maintenance of mitochondrial structure and function of the skeletal muscle

cell proliferation and apoptosis

and plays roles in multiple disease processes

such as nonalcoholic steatohepatitis (NASH) and tumor. Besides

KLF10 shows gender-dependent difference of regulation and function in many aspects. In this review

the biological functions of KLF10 and its roles in disease states is updated and discussed

which would provide new insights into the functional roles of KLF10 and a clearer view of potential therapeutic strategies by targeting KLF10.

关键词

Keywords

Adipose tissueEstrogen signalingGlucose and lipid metabolismNASHObesitySkeletal muscleTGFβ/SMAD signalingTumor

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Related Author

Zhou Yang

Guang-li Yu

Xiao Zhu

Tian-hong Peng

Yun-cheng Lv

Min Chen

Jieying Zhu

Hongyang Luo

Related Institution

Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University

Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical College, University of South China

School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport

Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China

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