nnexin A1

a well-known endogenous anti-inflammatory mediator

plays a critical role in a variety of pathological processes. Fibrosis is described by a failure of tissue regeneration and contributes to the development of many diseases. Accumulating evidence supports that Annexin A1 participates in the progression of tissue fibrosis. However

the fundamental mechanisms by which Annexin A1 regulates fibrosis remain elusive

and even the functions of Annexin A1 in fibrotic diseases are still paradoxical. This review focuses on the roles of Annexin A1 in the development of fibrosis of lung

liver

heart

and other tissues

with emphasis on the therapy potential of Annexin A1 in fibrosis

and presents future research interests and directions in fibrotic diseases.