Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (<em>PVT1</em>) in human diseases

Fang Wu; Yiping Zhu; Caiping Zhou; Weiwei Gui; Xihua Lin

doi:10.1016/j.gendis.2022.05.037

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Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (PVT1) in human diseases

Review article | 更新时间：2023-08-29

- Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (PVT1) in human diseases
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,Zhejiang,Hangzhou,China,310016
  2. Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,Zhejiang,Hangzhou,China,310016
  3. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,Zhejiang,Hangzhou,China,310016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.05.037
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
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Fang Wu, Yiping Zhu, Caiping Zhou, et al. Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (PVT1) in human diseases. [J]. Genes & Diseases 10(3).(2023)
DOI：

Fang Wu, Yiping Zhu, Caiping Zhou, et al. Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (PVT1) in human diseases. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2022.05.037.

摘要

Abstract

Plasmacytoma variant translocation 1 (

PVT1

) is a long non-coding RNA (lncRNA) gene identified as a recurrent breakpoint of Burkitt’s lymphomas. Human

PVT1

gene is located on region 8q24.21

a well-known cancer risk region

and encodes at least 26 linear ncRNA isoforms and 26 circular RNA isoforms

as well as 6 microRNAs. Several

PVT1

functioning models have been reported recently such as competing endogenous RNA (ceRNA) activity and regulating protein stability of oncogenes

especially

MYC

oncogene. The promoter of

PVT1

gene is a boundary element of tumor-suppressor DNA. CircPVT1 derived from

PVT1

gene is also a critical non-coding oncogenic RNA. Although substantial advancements have been made in understanding the roles of

PVT1

in cancer recently

the detailed mechanisms underlying its functions remain unclear. Herein

we summarize the recent progressions on the mechanisms underlying

PVT1

regulated gene expression at different levels. We also discuss the interaction between lncRNA and protein

RNA and DNA

as well as the potential cancer therapy strategy by targeting these networks.

关键词

Keywords

CancerCeRNACircPVT1Long non-coding RNAsMicroRNAsMYCPVT1Regulatory mechanism

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⁰

Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (PVT1) in human diseases

DOI：10.1016/j.gendis.2022.05.037

摘要

Abstract

关键词

Keywords

references