The role of circadian clocks in cancer: Mechanisms and clinical implications

Huiwen Liu; Ying Liu; Rihan Hai; Weihua Liao; Xiangjian Luo

doi:10.1016/j.gendis.2022.05.014

您当前的位置：

首页 >

文章列表页 >

The role of circadian clocks in cancer: Mechanisms and clinical implications

Review article | 更新时间：2023-08-29

- The role of circadian clocks in cancer: Mechanisms and clinical implications
- Genes & Diseases Vol. 10, Issue 4, (2023)
- 作者机构：
  
  1. Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan,Changsha,China,410078
  2. Department of Medicine, Hunan Traditional Chinese Medical College,Hunan,Zhuzhou,China,412000
  3. Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410078
  4. Molecular Imaging Research Center of Central South University,Hunan,Changsha,China,410078
  5. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Hunan,Changsha,China,410078
  6. Cancer Research Institute, School of Basic Medicine, Central South University,Hunan,Changsha,China,410078
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.05.014
  CLC：
- Published：2023，
  
  Published Online：1 July 2023，
扫描看全文
Huiwen Liu, Ying Liu, Rihan Hai, et al. The role of circadian clocks in cancer: Mechanisms and clinical implications. [J]. Genes & Diseases 10(4).(2023)
DOI：

Huiwen Liu, Ying Liu, Rihan Hai, et al. The role of circadian clocks in cancer: Mechanisms and clinical implications. [J]. Genes & Diseases 10(4).(2023) DOI： 10.1016/j.gendis.2022.05.014.

摘要

Abstract

Circadian rhythm refers to the inherent 24-h cycle oscillation of biochemical

physiological and behavioral functions

which is almost universal in eukaryotes. At least 14 core clock genes have been reported to form multiple chain feedback loops that confer intrinsic circadian rhythmicity onto the molecular clock. Accumulating evidence has shown that the circadian gene dysfunction resulted from single nucleotide polymorphisms (SNPs)

deletions

epigenetic modification

and deregulation is strongly associated with cancer risk. In the present review

we describe the composition of circadian rhythm system. We highlight the function and mechanism of clock genes in cancer pathogenesis and progression. Moreover

their potential clinical implications as prognostic biomarkers and therapeutic targets have been addressed.

关键词

Keywords

CancerCancer metabolismCircadian clockCircadian rhythmChronotherapyTumor microenvironment

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The emerging role of Arid5a in cancer: A new target for tumors

Metabolic reprogramming in tumors: Contributions of the tumor microenvironment

De novo nucleotide biosynthetic pathway and cancer

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

The generation and use of animal models of osteosarcoma in cancer research

Related Author

Kishan Kumar Nyati

Tadamitsu Kishimoto

Andrew N. Lane

Richard M. Higashi

Teresa W-M. Fan

Jie Chen

Siqi Yang

Yingge Li

Related Institution

Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 71

Center for Environmental and Systems Biochemistry, Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky

Cancer Center, Renmin Hospital of Wuhan University

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,,.C.

Department of Medical Oncology, Affiliated Hospital of Nantong University

⁰