The essential role of N6-methyladenosine RNA methylation in complex eye diseases

Xiaohua Li; Binyun Ma; Wenfang Zhang; Zongming Song; Xiaodan Zhang; Mengyu Liao; Xue Li; Xueru Zhao; Mei Du; Jinguo Yu; Shikun He; Hua Yan

doi:10.1016/j.gendis.2022.05.008

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The essential role of N6-methyladenosine RNA methylation in complex eye diseases

更新时间：2023-05-16

- The essential role of N6-methyladenosine RNA methylation in complex eye diseases
- Genes & Diseases Vol. 10, Issue 2, (2023)
- 作者机构：
  
  1. Department of Ophthalmology, Lanzhou University Second Hospital,Gansu,Lanzhou,China,730030
  2. Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University,Henan,Zhengzhou,China,450003
  3. Department of Ophthalmology, Tianjin Medical University General Hospital, Laboratory of Molecular Ophthalmology, Tianjin Medical University. Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University,Tianjin,China,300052
  4. Department of Pathology and Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California,CA,Los Angeles,USA,90033
  5. Department of Medicine/Hematology, Keck School of Medicine of the University of Southern California,CA,Los Angeles,USA,90033
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.05.008
  CLC：
- Published：2023，
  
  Published Online：1 March 2023，
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Xiaohua Li, Binyun Ma, Wenfang Zhang, et al. The essential role of N6-methyladenosine RNA methylation in complex eye diseases. [J]. Genes & Diseases 10(2).(2023)
DOI：

Xiaohua Li, Binyun Ma, Wenfang Zhang, et al. The essential role of N6-methyladenosine RNA methylation in complex eye diseases. [J]. Genes & Diseases 10(2).(2023) DOI： 10.1016/j.gendis.2022.05.008.

摘要

Abstract

There are many complex eye diseases which are the leading causes of blindness

however

the pathogenesis of the complex eye diseases is not fully understood

especially the underlying molecular mechanisms of N6-methyladenosine (m6A) RNA methylation in the eye diseases have not been extensive clarified. Our review summarizes the latest advances in the studies of m6A modification in the pathogenesis of the complex eye diseases

including cornea disease

cataract

diabetic retinopathy

age-related macular degeneration

proliferative vitreoretinopathy

Graves’ disease

uveal melanoma

retinoblastoma

and traumatic optic neuropathy. We further discuss the possibility of developing m6A modification signatures as biomarkers for the diagnosis of the eye diseases

as well as potential therapeutic approaches.

关键词

Keywords

DegenerationEye diseasesFibrosisInflammationm6A RNA methylationTumor

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