1. Division of Life Sciences and Medicine, University of Science and Technology of China, The First Affiliated Hospital of USTC,Anhui,Hefei,China,230001

2. School of Basic Medical Sciences, Anhui Medical University,Anhui,Hefei,China,230032

3. Institute of Clinical Pharmacology, Anhui Medical University,Anhui,Hefei,China,230032

4. Center for Biomedical Engineering and Technology, University of Maryland, Baltimore,MD,USA,21201

5. Department of Histology and Embryology, Institute of Stem Cell and Tissue Engineering, Anhui Medical University,Anhui,Hefei,China,230032