Histone post-translational modification and the DNA damage response

Haoyun Song; Rong Shen; Xiangwen Liu; Xuguang Yang; Kun Xie; Zhao Guo; Degui Wang

doi:10.1016/j.gendis.2022.04.002

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Histone post-translational modification and the DNA damage response

Review article | 更新时间：2023-08-29

- Histone post-translational modification and the DNA damage response
- Genes & Diseases Vol. 10, Issue 4, (2023)
- 作者机构：
  
  School of Basic Medical Sciences, Lanzhou University,Gansu,Lanzhou,China,730000
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.04.002
  CLC：
- Published：2023，
  
  Published Online：1 July 2023，
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Haoyun Song, Rong Shen, Xiangwen Liu, et al. Histone post-translational modification and the DNA damage response. [J]. Genes & Diseases 10(4).(2023)
DOI：

Haoyun Song, Rong Shen, Xiangwen Liu, et al. Histone post-translational modification and the DNA damage response. [J]. Genes & Diseases 10(4).(2023) DOI： 10.1016/j.gendis.2022.04.002.

摘要

Abstract

DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently. Human cells possess several DNA damage response (DDR) mechanisms to protect the integrity of their genome. Clarification of the mechanisms underlying the DNA damage response following lethal damage will facilitate the identification of therapeutic targets for cancers. Histone post-translational modifications (PTMs) have been indicated to play different roles in the repair of DNA damage. In this context

histone PTMs regulate recruitment of downstream effectors

and facilitate appropriate repair response. This review outlines the current understanding of different histone PTMs in response to DNA damage repair

besides

enumerates the role of new type PTMs such as histone succinylation and crotonylation in regulating DNA damage repair processes.

关键词

Keywords

DNA damageDNA damage responseHistonePost-translational modifications (PTMs)

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