KRAB-ZFPs and cancer stem cells identity

Anna Olechnowicz; Urszula Oleksiewicz; Marta Machnik

doi:10.1016/j.gendis.2022.03.013

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KRAB-ZFPs and cancer stem cells identity

Review article | 更新时间：2023-08-29

- KRAB-ZFPs and cancer stem cells identity
- Genes & Diseases Vol. 10, Issue 5, (2023)
- 作者机构：
  
  1. Department of Cancer Diagnostics and Immunology, Greater Poland Cancer Centre,Poznan,Poland,61-866
  2. Department of Cancer Immunology, Poznan University of Medical Sciences,Poznan,Poland,60-806
  3. Doctoral School, Poznan University of Medical Sciences,Poznan,Poland,60-812
  4. Department of Histology and Embryology, Poznan University of Medical Sciences,Poznan,Poland,60-781
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.03.013
  CLC：
- Published：2023，
  
  Published Online：1 September 2023，
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Anna Olechnowicz, Urszula Oleksiewicz, Marta Machnik. KRAB-ZFPs and cancer stem cells identity. [J]. Genes & Diseases 10(5).(2023)
DOI：

Anna Olechnowicz, Urszula Oleksiewicz, Marta Machnik. KRAB-ZFPs and cancer stem cells identity. [J]. Genes & Diseases 10(5).(2023) DOI： 10.1016/j.gendis.2022.03.013.

摘要

Abstract

Studies on carcinogenesis continue to provide new information about different disease-related processes. Among others

much research has focused on the involvement of cancer stem cells (CSCs) in tumor initiation and progression. Studying the similarities and differences between CSCs and physiological stem cells (SCs) allows for a better understanding of cancer biology. Recently

it was shown that stem cell identity is partially governed by the Krϋppel-associated box domain zinc finger proteins (KRAB-ZFPs)

the biggest family of transcription regulators. Several KRAB-ZFP factors exert a known effect in tumor cells

acting as tumor suppressor genes (TSGs) or oncogenes

yet their role in CSCs is still poorly characterized. Here

we review recent studies regarding the influence of KRAB-ZFPs and their cofactor protein TRIM28 on CSCs phenotype

stemness features

migration and invasion potential

metastasis

and expression of parental markers.

关键词

Keywords

CancerCancer stem cellEpigeneticKRAB-ZFPTranscription factors

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