Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities

Guo Zhao; Junfeng Zhen; Xinyuan Liu; Jinshuai Guo; Duanduan Li; Jianping Xie; Longxiang Xie

doi:10.1016/j.gendis.2022.03.009

您当前的位置：

首页 >

文章列表页 >

Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities

Review article | 更新时间：2023-08-29

- Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities
- Genes & Diseases Vol. 10, Issue 4, (2023)
- 作者机构：
  
  1. Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University,Henan,Kaifeng,China,475004
  2. State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Institute of Modern Biopharmaceuticals, Ministry of Education, School of Life Sciences, Southwest University,Chongqing,China,400715
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.03.009
  CLC：
- Published：2023，
  
  Published Online：1 July 2023，
扫描看全文
Guo Zhao, Junfeng Zhen, Xinyuan Liu, et al. Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities. [J]. Genes & Diseases 10(4).(2023)
DOI：

Guo Zhao, Junfeng Zhen, Xinyuan Liu, et al. Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities. [J]. Genes & Diseases 10(4).(2023) DOI： 10.1016/j.gendis.2022.03.009.

摘要

Abstract

Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism physiology and some pathophysiological processes

such as tumorigenesis and metabolic diseases. To provide an understanding of the molecular mechanism and functions of Ksuc in different organisms

we reviewed the current literature about Ksuc

mainly summarizing the research advances in eukaryotes and prokaryotes based on both traditional study methods and site prediction tools. We also discussed inhibitors or activators associated with Ksuc that may contribute to proteomic studies and could be useful in future clinical practice. A deeper understanding of Ksuc may shed new light on life science at the protein level and could lead to novel therapeutic strategies for various diseases.

关键词

Keywords

DiseaseEukaryotesLysine succinylationPhysiologyProkaryotesProtein post-translational modification

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

Enzymatic and metabolic regulation of lysine succinylation

Related Author

Piao Zhao

Tong-Chuan He

Russell R. Reid

Jason Strelzow

Michael J. Lee

Sherwin Ho

Hue H. Luu

Rex C. Haydon

Related Institution

Department of Urology, The First Affiliated Hospital of Chongqing Medical University

School of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago

Department of Clinical Laboratory Medicine, Shanghai Jiaotong University School of Medicine

Laboratory of Craniofacial Suture Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center

Department of Neurology, The First Dongguan Affiliated Hospital, Guangdong Medical University

⁰