Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Amoolya Kandettu; Divya Adiga; Vasudha Devi; Padmanaban S. Suresh; Sanjiban Chakrabarty; Raghu Radhakrishnan; Shama Prasada Kabekkodu

doi:10.1016/j.gendis.2021.12.026

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Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

更新时间：2022-11-09

- Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine
- Genes & Diseases Vol. 9, Issue 6, (2022)
- 作者机构：
  
  1. Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka,India,576104
  2. Department of Pharmacology, Centre for Cardiovascular Pharmacology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal Campus, Manipal, Karnataka,India,576104
  3. School of Biotechnology, National Institute of Technology, Calicut, Kerala,India,673601
  4. Center for DNA Repair and Genome Stability (CDRGS), Manipal Academy of Higher Education, Manipal, Karnataka,India,576104
  5. Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka,India,576104
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.026
  CLC：
- Published：2022，
  
  Published Online：1 November 2022，
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Amoolya Kandettu, Divya Adiga, Vasudha Devi, et al. Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine. [J]. Genes & Diseases 9(6).(2022)
DOI：

Amoolya Kandettu, Divya Adiga, Vasudha Devi, et al. Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine. [J]. Genes & Diseases 9(6).(2022) DOI： 10.1016/j.gendis.2021.12.026.

摘要

Abstract

Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease

making it highly lethal. miRNAs are single-stranded

small non-coding RNAs with an approximate size ranging around 22 nt. Interestingly

a considerable proportion of miRNAs are organized in clusters with miRNA genes placed adjacent to one another

getting transcribed together to result in miRNA clusters (MCs). MCs comprise two or more miRNAs that follow the same orientation during transcription. Abnormal expression of the miRNA cluster has been identified as one of the key drivers in OC. MC exists both as tumor-suppressive and oncogenic clusters and has a significant role in OC pathogenesis by facilitating cancer cells to acquire various hallmarks. The present review summarizes the regulation and biological function of MCs in OC. The review also highlights the utility of abnormally expressed MCs in the clinical management of OC.

关键词

Keywords

DiagnosisDrug resistancemiRNA clustersOvarian cancerPrognosisRegulation

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