Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system

Zicai Dong; Chuan Yang; Jiulin Tan; Ce Dou; Yueqi Chen

doi:10.1016/j.gendis.2021.12.024

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Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system

Review article | 更新时间：2023-08-29

- Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Department of Biomedical Materials Science, Army Medical University,Chongqing,China,400038
  2. Department of Orthopedics, Southwest Hospital, Army Medical University,Chongqing,China,400038
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.024
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
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Zicai Dong, Chuan Yang, Jiulin Tan, et al. Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system. [J]. Genes & Diseases 10(3).(2023)
DOI：

Zicai Dong, Chuan Yang, Jiulin Tan, et al. Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2021.12.024.

摘要

Abstract

The skeletal system is a dynamically balanced system

which undergoes continuous bone resorption and formation to maintain bone matrix homeostasis. As an important ADP-ribosylase and NAD

-dependent deacylase

SIRT6 (SIR2-like protein 6) is widely expressed on various kinds of bone cells

such as chondrocytes

osteoblasts

osteoclasts. The aberration of SIRT6 impairs gene expression (e.g.

NF-κB and Wnt target genes) and cellular functions (e.g.

DNA repair

glucose and lipid metabolism

telomeric maintenance)

which disturbs the dynamic balance and ultimately leads to several bone-related diseases. In this review

we summarize the critical roles of SIRT6 in the onset and progression of bone-related diseases including osteoporosis

osteoarthritis

rheumatoid arthritis

and intervertebral disc degeneration

as well as the relevant signaling pathways. In addition

we discuss the advances in the development of SIRT6 activators and elucidate their pharmacological profiles

which may provide novel treatment strategies for these skeletal diseases.

关键词

Keywords

Intervertebral disc degeneration (IDD)Osteoarthritis (OA)Osteoporosis (OP)Rheumatoid arthritis (RA)SIRT6 (SIR2-Like protein 6)SIRT6 activator

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