Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer

Shuman Li; Xiaoqian He; Yan Wang; Weihong Chen; Ran Sun; Shaorong Tian; Sanxiu He; Chunyun Pu; Chen Li; Dishu Zhou; Yu Jiang; Qian Tao; Lili Li; Lin Ye; Yue Wu; Weiyan Peng; Tingxiu Xiang

doi:10.1016/j.gendis.2021.12.019

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Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer

更新时间：2023-05-16

- Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer
- Genes & Diseases Vol. 10, Issue 2, (2023)
- 作者机构：
  
  1. Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
  2. Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
  3. Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong and CUHK Shenzhen Research Institute,Guangdong,Shenzhen,China,518172
  4. Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital,Chongqing,China,400030
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.019
  CLC：
- Published：2023，
  
  Published Online：1 March 2023，
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Shuman Li, Xiaoqian He, Yan Wang, et al. Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer. [J]. Genes & Diseases 10(2).(2023)
DOI：

Shuman Li, Xiaoqian He, Yan Wang, et al. Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer. [J]. Genes & Diseases 10(2).(2023) DOI： 10.1016/j.gendis.2021.12.019.

摘要

Abstract

Our previous studies found that Zinc-finger protein 382 (ZNF382) played as a tumor suppressor gene in esophageal and gastric cancers

and a positive correlation between the high expression of ZNF382 and better outcome in breast cancer patients. However

the biological roles and mechanisms of ZNF382 in breast cancer remains unclear. We detected ZNF382 expression by reverse-transcription PCR (RT-PCR) and real-time quantitative PCR (qRT-PCR) in breast cancer cells and tissues

and explored the impacts and mechanisms of ectopic ZNF382 expression in breast cancer cells

in vitro

and

in vivo

respectively. Our results revealed that ZNF382 was significantly down-regulated in breast cancer tissues compared with adjacent non-cancer tissues. Restoration of ZNF382 expression in silenced breast cancer cells not only inhibited tumor cell colony formation

viability

migration and invasion

and epithelial-mesenchymal-transition (EMT)

but also induced apoptosis and G0/G1 arrest. In conclusion

ZNF382 could induce G0/G1 cell cycle arrest through inhibiting CDC25A signaling

and

inhibit cell migration

invasion and EMT by antagonizing ZEB1 signaling in breast cancer cells.

关键词

Keywords

Breast cancerCDC25AEMTZEB1ZNF382

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