Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective

Yao Zhang; Yibing Wang; Junli Liu

doi:10.1016/j.gendis.2021.12.011

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Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective

Review article | 更新时间：2023-08-29

- Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai,China,200233
  2. School of Kinesiology, Shanghai University of Sport,Shanghai,China,200438
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.011
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
扫描看全文
Yao Zhang, Yibing Wang, Junli Liu. Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective. [J]. Genes & Diseases 10(3).(2023)
DOI：

Yao Zhang, Yibing Wang, Junli Liu. Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2021.12.011.

摘要

Abstract

Due to excess energy intake and a sedentary lifestyle

the prevalence of obesity is rising steadily and has emerged as a global public health problem. Adipose tissue undergoes structural remodeling and dysfunction in the obese state. Secreted proteins derived from the liver

also termed as hepatokines

exert multiple effects on adipose tissue remodeling and the development of obesity

and has drawn extensive attention for their therapeutic potential in the treatment of obesity and related diseases. Several novel hepatokines and their functions on systemic metabolism have been interrogated recently as well. The drug development programs targeting hepatokines also have shown inspiring benefits in obesity treatment. In this review

we outline how adipose tissue changes during obesity. Then

we summarize and critically analyze the novel findings on the effects of metabolic “beneficial” and metabolic “harmful” hepatokines to adipose tissue. We also discuss the in-depth molecular mechanism that hepatokines may mediate the liver-adipose tissue crosstalk

the novel technologies targeting hepatokines and their receptors

in vivo

to explore their functions

and the potential application of these interventions in clinical practice.

关键词

Keywords

FGF21HepatokineLiver-adipose tissue crosstalkObesityTherapeutic strategy

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