tRNA-derived small RNAs: Mechanisms and potential roles in cancers

Yao Wang; Qiuyan Weng; Jiaxin Ge; Xinjun Zhang; Junming Guo; Guoliang Ye

doi:10.1016/j.gendis.2021.12.009

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tRNA-derived small RNAs: Mechanisms and potential roles in cancers

更新时间：2022-11-09

- tRNA-derived small RNAs: Mechanisms and potential roles in cancers
- Genes & Diseases Vol. 9, Issue 6, (2022)
- 作者机构：
  
  1. Department of Biochemistry and Molecular Biology, And Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University,Zhejiang,Ningbo,PR China,315211
  2. Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine,Zhejiang,Ningbo,PR China,315020
  3. Institute of Digestive Diseases of Ningbo University,Zhejiang,Ningbo,PR China,315020
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.009
  CLC：
- Published：2022，
  
  Published Online：1 November 2022，
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Yao Wang, Qiuyan Weng, Jiaxin Ge, et al. tRNA-derived small RNAs: Mechanisms and potential roles in cancers. [J]. Genes & Diseases 9(6).(2022)
DOI：

Yao Wang, Qiuyan Weng, Jiaxin Ge, et al. tRNA-derived small RNAs: Mechanisms and potential roles in cancers. [J]. Genes & Diseases 9(6).(2022) DOI： 10.1016/j.gendis.2021.12.009.

摘要

Abstract

Transfer RNAs (tRNAs) are essential for protein synthesis. Mature or pre-tRNAs may be cleaved to produce tRNA-derived small RNAs (tsRNAs). tsRNAs

divided into tRNA-derived stress-induced RNA (tiRNAs) and tRNA-derived fragments (tRFs)

play versatile roles in a number of fundamental biological processes. tsRNAs not only play regulatory roles in gene silencing

RNA stability

reverse transcription

and translation

but are also closely related to cell proliferation

migration

cell cycle

and apoptosis. Their abnormal expression is associated with the occurrence and development of various human diseases

especially cancer. This paper reviews the classification

biogenesis

and mechanism of action of tsRNAs

and the research progress to date on tsRNAs in cancers. These findings provide new opportunities for diagnostic biomarkers and treatment targets of several types of cancers including gastric cancer

colorectal cancer

hepatocellular carcinomas

pancreatic cancer

breast cancer

prostate cancer

renal cell carcinoma

ovarian cancer

lung cancer

bladder cancer

thyroid cancer

oral cancer

and leukemia.

关键词

Keywords

BiomarkerCancerGene expressiontRNAtsRNA

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