Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis

Can Xu; Heng Li; Chao-Ke Tang

doi:10.1016/j.gendis.2021.12.007

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Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis

更新时间：2023-05-16

- Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis
- Genes & Diseases Vol. 10, Issue 2, (2023)
- 作者机构：
  
  Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, The First Affiliated Hospital of University of South China, Department of Cardiology, Hengyang Medical School, University of South China,Hunan,Hengyang,China,421001
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.007
  CLC：
- Published：2023，
  
  Published Online：1 March 2023，
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Can Xu, Heng Li, Chao-Ke Tang. Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis. [J]. Genes & Diseases 10(2).(2023)
DOI：

Can Xu, Heng Li, Chao-Ke Tang. Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis. [J]. Genes & Diseases 10(2).(2023) DOI： 10.1016/j.gendis.2021.12.007.

摘要

Abstract

herosclerosis

the underlying pathophysiological basis of cardiovascular disease

has been recognized as a lipid-driven chronic inflammatory disease. Sterol carrier protein 2 (SCP-2) is a 13-kDa non-specific lipid-transfer protein expressed by various tissues and cells

such as liver

heart

vascular smooth muscle cells (VSMCs)

and macrophages. SCP-2 has an extensive role in cardiovascular and metabolic diseases. Recently

SCP-2 was reported to promote the development of atherosclerosis by regulating lipid metabolism and peroxidation

endocannabinoid metabolism

vascular inflammation

and fatty acid metabolism. In this review

we summarized the recent advances regarding the role of SCP-2 in the pathogenesis of atherosclerosis and tried to provide a rationale for future investigation and a better understanding of the biological functions of SCP-2 in atherosclerotic cardiovascular disease.

关键词

Keywords

AtherosclerosisFatty acid metabolismLipid metabolismSCP-2Vascular inflammation

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