New insights into the roles for DYRK family in mammalian development and congenital diseases

Saishu Yoshida; Kiyotsugu Yoshida

doi:10.1016/j.gendis.2021.12.004

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New insights into the roles for DYRK family in mammalian development and congenital diseases

Review article | 更新时间：2023-08-29

- New insights into the roles for DYRK family in mammalian development and congenital diseases
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  Department of Biochemistry, The Jikei University School of Medicine, Minato-, Tokyo 61,ku,Japan,105 84
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.004
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
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Saishu Yoshida, Kiyotsugu Yoshida. New insights into the roles for DYRK family in mammalian development and congenital diseases. [J]. Genes & Diseases 10(3).(2023)
DOI：

Saishu Yoshida, Kiyotsugu Yoshida. New insights into the roles for DYRK family in mammalian development and congenital diseases. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2021.12.004.

摘要

Abstract

The dual-specificity tyrosine-regulated kinase (DYRK) family is evolutionarily conserved from invertebrate to mammals. DYRKs regulate cell proliferation

apoptosis

survival

and differentiation by modifying the protein activation state

cellular localization

and turnover. In contrast to several studies in cellular models

the available evidence regarding the

in vivo

roles of DYRKs in mammalian development is limited. This review summarizes the

in vivo

studies on

Dyrks

which provide insight into their roles in mammalian tissue development and congenital diseases.

In vivo

evidence obtained using knockout and genetically modified animals helps to understand and develop novel clinical therapies and drug for human congenital diseases

such as Down syndrome and neuronal disorders (associated with DYRK1A) and skeletal ciliopathies (associated with DYRK2).

关键词

Keywords

CiliopathiesDevelopmentDown syndromeDYRKsEmbryogenesis

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