Oncolytic viruses: A novel treatment strategy for breast cancer

Mohammad Javanbakht; Sanaz Tahmasebzadeh; Luca Cegolon; Nasrin Gholami; Mandana Kashaki; Hassan Nikoueinejad; Mohamad Mozafari; Mahsa Mozaffari; Shi Zhao; Mostafa Khafaei; Morteza Izadi; Saeid Fathi; Reza Akhavan-Sigari

doi:10.1016/j.gendis.2021.11.011

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Oncolytic viruses: A novel treatment strategy for breast cancer

更新时间：2023-05-16

- Oncolytic viruses: A novel treatment strategy for breast cancer
- Genes & Diseases Vol. 10, Issue 2, (2023)
- 作者机构：
  
  1. Health Research Center, Baqiyatallah University of Medical Sciences, Tehran 143591,Iran,6471
  2. JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong Special Administrative Region,China,999077
  3. Department of Pediatrics, Iran University of Medical Sciences, Tehran 144961,Iran,4535
  4. Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran 169875,Iran,931
  5. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz 516795,Iran,6561
  6. Department of General Surgery, Urmia University of Medical Science, Urmia,Iran,57147
  7. Razi Vaccine and Serum Research Institute, Agriculture Research, Education and Extension Organization (AREEO), Karaj,Iran,11365-1558
  8. Department of Neurosurgery, University Medical Center, Tuebingen,Germany,72076
  9. University of Trieste, Department of Medical, Surgical & Health Sciences,Trieste,Italy,34128
  10. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran 143591,Iran,6471
  11. University Health Agency Giuliano-Isontina (ASUGI), Public Health Department,Trieste,Italy
  12. Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran 199767,Iran,3144
  13. Mehrestan Health Network, Iranshahr University of Medical Sciences, Iranshahr 996611,Iran,8984
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.11.011
  CLC：
- Published：2023，
  
  Published Online：1 March 2023，
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Mohammad Javanbakht, Sanaz Tahmasebzadeh, Luca Cegolon, et al. Oncolytic viruses: A novel treatment strategy for breast cancer. [J]. Genes & Diseases 10(2).(2023)
DOI：

Mohammad Javanbakht, Sanaz Tahmasebzadeh, Luca Cegolon, et al. Oncolytic viruses: A novel treatment strategy for breast cancer. [J]. Genes & Diseases 10(2).(2023) DOI： 10.1016/j.gendis.2021.11.011.

摘要

Abstract

Breast cancer

an unceasingly occurring neoplasm

is one of the major determinants of mortality in women. Several ineffective attempts have been pursued using with conventional therapies against breast cancer. Resistance to existing therapies and their respective debilitating adverse effects have led research toward a new era of cancer treatment using viruses. Virotherapy constitutes a developing treatment modality with multiple mechanisms of therapeutic activity in which the viruses can be directly oncolyticand can express transgenes or induce host immune response against tumor cells. Several different DNA- and RNA-containing viruses have been considered for virotherapy of breast cancer including adenovirus

herpes virus

vaccinia

reovirus

Newcastle Disease virus

measles virus and vesicular stomatitis virus. This review aims to summarize the viro-therapeutical agents against breast malignancies. Key Scientific Concepts of Review: In this review paper

we proposed a new strategy to virus's combinatorial treatments using several kinds of transgenes and drugs. These recombinant viruses have provided evidence of treatment efficacy against human breast cancer.

关键词

Keywords

AdenovirusBreast cancerHerpes virusMeasles virusNewcastle disease virusReovirusVacciniaVesicular stomatitis virusVirotherapy

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