Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera

Jie Hu; Xiao-yu Wei; Jin Xiang; Pai Peng; Feng-li Xu; Kang Wu; Fei-yang Luo; Ai-shun Jin; Liang Fang; Bei-zhong Liu; Kai Wang; Ni Tang; Ai-Long Huang

doi:10.1016/j.gendis.2021.11.007

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Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera

更新时间：2022-08-11

- Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera
- Genes & Diseases Vol. 9, Issue 5, (2022)
- 作者机构：
  
  1. Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University,Chongqing,PR China,400010
  2. Yong-Chuan Hospital, Chongqing Medical University,Chongqing,PR China,402177
  3. Department of Immunology, College of Basic Medicine, Chongqing Medical University,Chongqing,PR China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.11.007
  CLC：
- Published：2022，
  
  Published Online：1 September 2022，
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Jie Hu, Xiao-yu Wei, Jin Xiang, et al. Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera. [J]. Genes & Diseases 9(5).(2022)
DOI：

Jie Hu, Xiao-yu Wei, Jin Xiang, et al. Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera. [J]. Genes & Diseases 9(5).(2022) DOI： 10.1016/j.gendis.2021.11.007.

摘要

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The Spike protein that mediates coronavirus entry into host cells is a major target for COVID-19 vaccines and antibody therapeutics. However

multiple variants of SARS-CoV-2 have emerged

which may potentially compromise vaccine effectiveness. Using a pseudovirus-based assay

we evaluated SARS-CoV-2 cell entry mediated by the viral Spike B.1.617 and B.1.1.7 variants. We also compared the neutralization ability of monoclonal antibodies from convalescent sera and neutralizing antibodies (NAbs) elicited by CoronaVac (inactivated vaccine) and ZF2001 (RBD-subunit vaccine) against B.1.617 and B.1.1.7 variants. Our results showed that

compared to D614G and B.1.1.7 variants

B.1.617 shows enhanced viral entry and membrane fusion

as well as more resistant to antibody neutralization. These findings have important implications for understanding viral infectivity and for immunization policy against SARS-CoV-2 variants.

关键词

Keywords

CoronavirusImmune escapeMutationNeutralizing antibodiesSARS-Cov-2VaccineViral entry

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