LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy

Xin Huang; Weiyue Zhang; Feifei Pu; Zhicai Zhang

doi:10.1016/j.gendis.2021.11.004

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LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy

更新时间：2023-05-16

- LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy
- Genes & Diseases Vol. 10, Issue 2, (2023)
- 作者机构：
  
  1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China,430022
  2. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China,430022
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.11.004
  CLC：
- Published：2023，
  
  Published Online：1 March 2023，
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Xin Huang, Weiyue Zhang, Feifei Pu, et al. LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy. [J]. Genes & Diseases 10(2).(2023)
DOI：

Xin Huang, Weiyue Zhang, Feifei Pu, et al. LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy. [J]. Genes & Diseases 10(2).(2023) DOI： 10.1016/j.gendis.2021.11.004.

摘要

Abstract

This study aimed to investigate the role of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) in chemosensitivity of osteosarcoma (OS)

and to reveal the possible underlying mechanisms. In this study

we found that the expression of lncRNA MEG3 was significantly lower in OS tissues and cell lines. Furthermore

lncRNA MEG3 overexpression enhanced chemosensitivity of OS by inhibiting cell proliferation

migration

autophagy

and promoting antitumor immunity. LncRNA MEG3 functioned as miR-21-5 sponge to regulate p53 expression in OS. Mechanically

lncRNA MEG3 promoted OS chemosensitivity by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy. Collectively

this study provided the evidence that lncRNA MEG3 might be a promising therapeutic target for OS chemoresistance.

关键词

Keywords

Antitumor immunityAutophagyChemosensitivityLncRNAMEG3Osteosarcoma

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Related Institution

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University

Department of Orthopedics, Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital), Tongji Medical College, Huazhong University of Science and Technology

Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University

Institute of Organ Transplantation, Zhejiang University

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