The role of autophagy in regulating metabolism in the tumor microenvironment

Panpan Zhang; Shanshan Cheng; Xiaonan Sheng; Huijuan Dai; Kang He; Yueyao Du

doi:10.1016/j.gendis.2021.10.010

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The role of autophagy in regulating metabolism in the tumor microenvironment

更新时间：2023-05-16

- The role of autophagy in regulating metabolism in the tumor microenvironment
- Genes & Diseases Vol. 10, Issue 2, (2023)
- 作者机构：
  
  1. Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai,China,200127
  2. Department of Gynecology and Obstetrics, Shanghai Key Laboratory of Gynecology Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai,China,200127
  3. Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1630 Dongfang Road,Shanghai,China,200127
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.10.010
  CLC：
- Published：2023，
  
  Published Online：1 March 2023，
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Panpan Zhang, Shanshan Cheng, Xiaonan Sheng, et al. The role of autophagy in regulating metabolism in the tumor microenvironment. [J]. Genes & Diseases 10(2).(2023)
DOI：

Panpan Zhang, Shanshan Cheng, Xiaonan Sheng, et al. The role of autophagy in regulating metabolism in the tumor microenvironment. [J]. Genes & Diseases 10(2).(2023) DOI： 10.1016/j.gendis.2021.10.010.

摘要

Abstract

utophagy

as a special programmed cell death

is a critical degradative process that eliminates intracellular abnormal proteins or damage organelles to balance cell energy and favor cell metabolism with autophagy-related (ATG) proteins. Autophagy activation is being increasingly recognized as an essential hallmark in tumorigenesis through influencing the metabolism of stromal cells in the tumor microenvironment (TME) which comprises of tumor cells

cancer-associated fibroblasts (CAFs)

cancer-associated endothelial cells (CAEs)

immune cells and adipocytes. Tumor cells can reuse autophagy-involved recycling to maintain mitochondrial function and energy supply to meet the metabolic demand of their growth and proliferation. However

the mechanism through which autophagy can promote a crosstalk between tumor and stroma cells is not clear. Reprogramed metabolism is one of the main characteristics of TME leading to higher adaptability of tumor cells with diverse mechanisms. The activation of autophagy has expanded our understanding on the interaction between tumor metabolism and TME. The aim of this review is to report recent advances on the metabolic cross-talk between stromal cells and solid tumor cells induced by autophagy in TME and revealed potential therapeutic targets.

关键词

Keywords

AutophagyMetabolismTherapeutic targetsTumorTumor microenvironment

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