MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers

Mehdi Sajjadi-Dokht; Talar Ahmad Merza Mohamad; Heshu Sulaiman Rahman; Marwah Suliman Maashi; Svetlana Danshina; Navid Shomali; Saeed Solali; Faroogh Marofi; Elham Zeinalzadeh; Morteza Akbari; Ali Adili; Ramin Aslaminabad; Majid Farshdousti Hagh; Mostafa Jarahian

doi:10.1016/j.gendis.2021.10.009

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MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers

更新时间：2022-06-24

- MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers
- Genes & Diseases Vol. 9, Issue 4, (2022)
- 作者机构：
  
  1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 516661,Iran,4766
  2. Department of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil,Iraq,44001
  3. Department of Physiology, College of Medicine, University of Sulaymaniyah, Sulaymaniyah,Iraq,46001
  4. Department of Medical Laboratory Sciences, Komar University of Science and Technology, Sulaymaniyah,Iraq,46002
  5. Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah 21589, Saudi Arabia
  6. Department of Propaedeutics of Dental Diseases, I. M. Sechenov First Moscow State Medical University,Moscow,Russia,119991
  7. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 516661,Iran,4766
  8. Department of Oncology, Tabriz University of Medical Sciences, Tabriz 516661,Iran,4766
  9. German Cancer Research Center (DKFZ), Toxicology and Chemotherapy Unit (G401), Heidelberg,Germany,69120
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.10.009
  CLC：
- Published：2022，
  
  Published Online：1 July 2022，
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Mehdi Sajjadi-Dokht, Talar Ahmad Merza Mohamad, Heshu Sulaiman Rahman, et al. MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers. [J]. Genes & Diseases 9(4).(2022)
DOI：

Mehdi Sajjadi-Dokht, Talar Ahmad Merza Mohamad, Heshu Sulaiman Rahman, et al. MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers. [J]. Genes & Diseases 9(4).(2022) DOI： 10.1016/j.gendis.2021.10.009.

摘要

Abstract

Blood disorders include a wide spectrum of blood-associated malignancies resulting from inherited or acquired defects. The ineffectiveness of existing therapies against blood disorders arises from different reasons

one of which is drug resistance

so different types of leukemia may show different responses to treatment. Leukemia occurs for a variety of genetic and acquired reasons

leading to uncontrolled proliferation in one or more cell lines. Regarding the genetic defects

oncogene signal transducer and activator of transcription (STAT) family transcription factor

especially STAT3

play an essential role in hematological disorders onset and progress upon mutations

dysfunction

or hyperactivity. Besides

microRNAs

as biological molecules

has been shown to play a dual role in either tumorigenesis and tumor suppression in various cancers. Besides

a strong association between STAT3 and miRNA has been reported. For example

miRNAs can regulate STAT3 via targeting its upstream mediators such as IL6

IL9

and JAKs or directly binding to the

STAT3

gene. On the other hand

STAT3 can regulate miRNAs. In this review study

we aimed to determine the role of either microRNAs and STAT3 along with their effect on one another's activity and function in hematological malignancies.

关键词

Keywords

InterleukinJAKsLeukemiamiRNAsSTAT3

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