N6-methyladenosine (m6A) modification of ribosomal RNAs (rRNAs): Critical roles in mRNA translation and diseases

Kexin Lei; Shuibin Lin; Quan Yuan

doi:10.1016/j.gendis.2021.10.005

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N6-methyladenosine (m6A) modification of ribosomal RNAs (rRNAs): Critical roles in mRNA translation and diseases

更新时间：2023-08-29

- N6-methyladenosine (m6A) modification of ribosomal RNAs (rRNAs): Critical roles in mRNA translation and diseases
- Genes & Diseases Vol. 10, Issue 1, (2023)
- 作者机构：
  
  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
  2. Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou,China,510080
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.10.005
  CLC：
- Published：2023，
  
  Published Online：1 January 2023，
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Kexin Lei, Shuibin Lin, Quan Yuan. N6-methyladenosine (m6A) modification of ribosomal RNAs (rRNAs): Critical roles in mRNA translation and diseases. [J]. Genes & Diseases 10(1).(2023)
DOI：

Kexin Lei, Shuibin Lin, Quan Yuan. N6-methyladenosine (m6A) modification of ribosomal RNAs (rRNAs): Critical roles in mRNA translation and diseases. [J]. Genes & Diseases 10(1).(2023) DOI： 10.1016/j.gendis.2021.10.005.

摘要

Abstract

key components of the ribosome and the most abundant RNA species

the rRNAs are modified during ribosome formation. N

-methyladenosine (m

A) is a conserved RNA modification occurring on different RNA species including rRNAs. Recently

it has been reported that ZCCHC4 and METTL5 are methyltransferases that mediate m

A modification of human 28S and 18S rRNA

respectively. The newly discovered biological functions of the two methyltransferases include regulation of mRNA translation

cell proliferation

cell differentiation

stress response

and other biological processes. Both of them

especially METTL5

have been proved to be associated with a variety of diseases such as intellectual disability

cancer

congenital dysplasia and have potential clinical application as biomarkers and therapeutic targets.

关键词

Keywords

Biological processesDiseasesm6AMETTL5ZCCHC4

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