Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response

Yuanliang Yan; Jinwu Peng; Qiuju Liang; Xinxin Ren; Yuan Cai; Bi Peng; Xi Chen; Xiang Wang; Qiaoli Yi; Zhijie Xu

doi:10.1016/j.gendis.2021.10.004

您当前的位置：

首页 >

文章列表页 >

Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response

更新时间：2023-08-29

- Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response
- Genes & Diseases Vol. 10, Issue 1, (2023)
- 作者机构：
  
  1. Department of Pharmacy, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  2. Department of Pathology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  3. Department of Pathology, Xiangya Changde Hospital,Hunan,Changde,China,415000
  4. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  5. Center for Molecular Medicine, Xiangya Hospital, Key Laboratory of Molecular Radiation Oncology of Hunan Province, Central South University,Hunan,Changsha,China,410008
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.10.004
  CLC：
- Published：2023，
  
  Published Online：1 January 2023，
扫描看全文
Yuanliang Yan, Jinwu Peng, Qiuju Liang, et al. Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response. [J]. Genes & Diseases 10(1).(2023)
DOI：

Yuanliang Yan, Jinwu Peng, Qiuju Liang, et al. Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response. [J]. Genes & Diseases 10(1).(2023) DOI： 10.1016/j.gendis.2021.10.004.

摘要

Abstract

Several types of modifications have been proven to participate in the metabolism and processing of different RNA types

including non-coding RNAs (ncRNAs). N-6-methyladenosine (m6A) is a dynamic and reversible RNA modification that is closely involved in the ncRNA homeostasis

and serves as a crucial regulator for multiple cancer-associated signaling pathways. The ncRNAs usually regulate the epigenetic modification

mRNA transcription and other biological processes

displaying enormous roles in human cancers. In this review

we summarized the significant implications of m6A-ncRNA interaction in various types of cancers. In particular

the interplay between m6A and ncRNAs in cancer pathogenesis and therapeutic resistance are being widely recognized. We also discussed the relevance of m6A-ncRNA interaction in immune regulation

followed by the interference on cancer immunotherapeutic procedures. In addition

we briefly highlighted the computation tools that could identify the accurate features of m6A methylome among ncRNAs. In summary

this review would pave the way for a better understanding of the biological functions of m6A-ncRNA crosstalk in cancer research and treatment.

关键词

Keywords

CancerImmune regulationN-6-MethyladenosineNon-coding RNAsTherapeutic response

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

De novo nucleotide biosynthetic pathway and cancer

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

The generation and use of animal models of osteosarcoma in cancer research

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Synthetic lethal approaches to target cancers with loss of PTEN function

Related Author

Jie Chen

Siqi Yang

Yingge Li

Xu Ziwen

Pingfeng Zhang

Qibin Song

Yi Yao

Huadong Pei

Related Institution

Cancer Center, Renmin Hospital of Wuhan University

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,,.C.

Department of Medical Oncology, Affiliated Hospital of Nantong University

Medical School of Nantong University, Nantong University

Research Center of Clinical Medicine, Affiliated Hospital of Nantong University

⁰