Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe−/− mice

Kun Zhang; Xian Qin; Juhui Qiu; Tong Sun; Kai Qu; Ahmad Ud Din; Wenhua Yan; Tianhan Li; Yidan Chen; Wei Gu; Xiancai Rao; Guixue Wang

doi:10.1016/j.gendis.2021.09.007

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Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe−/− mice

更新时间：2023-08-29

- Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe−/− mice
- Genes & Diseases Vol. 10, Issue 1, (2023)
- 作者机构：
  
  1. Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University,Chongqing,China,400044
  2. College of Information and Management Sciences, Henan Agricultural University,Henan,Zhengzhou,China,450046
  3. School of Medicine, Chongqing University,Chongqing,China,400030
  4. Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University),Chongqing,China,400037
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.09.007
  CLC：
- Published：2023，
  
  Published Online：1 January 2023，
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Kun Zhang, Xian Qin, Juhui Qiu, et al. Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe−/− mice. [J]. Genes & Diseases 10(1).(2023)
DOI：

Kun Zhang, Xian Qin, Juhui Qiu, et al. Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe−/− mice. [J]. Genes & Diseases 10(1).(2023) DOI： 10.1016/j.gendis.2021.09.007.

摘要

Abstract

It is increasingly aware that gut microbiota is closely associated with atherosclerosis. However

which and how specific gut bacteria regulate the progression of atherosclerosis is still poorly understood. In this study

modified linear discriminant analysis was performed in comparing the gut microbiota structures of atherosclerotic and non-atherosclerotic mice

and

Desulfovibrio desulfuricans

(

D. desulfuricans

) was found to be associated with atherosclerosis.

D. desulfuricans-

treated

Apoe

−/−

mice showed significantly aggravated atherosclerosis. The proatherogenic effect of

D. desulfuricans

was attributed to its ability to increase intestinal permeability and subsequent raise in the transit of lipopolysaccharide (LPS) from the intestine to the bloodstream. Excessive LPS in the blood can elicit local and systemic inflammation and activate Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling of endothelial cells. TAK-242

a specific inhibitor of TLR4

can ameliorate the development of

D. desulfuricans

-induced atherosclerosis by blocking the LPS-induced activation of TLR4/NF-κB signaling.

关键词

Keywords

AtherosclerosisDesulfovibrio desulfuricansGut microbiotaLinear discriminant analysisTAK-242

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Related Institution

College of Basic Medical Sciences, Chongqing Medical University

Department of Neurosurgery, Daping Hospital, Army Medical Center of PLA, Army Medical University

Key Laboratory of Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University

Department of Vascular & Intervention, Tenth Peoples' Hospital of Tongji University

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University

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