The potential regulatory role of BMP9 in inflammatory responses

Tianzhu Song; Dingming Huang; Dongzhe Song

doi:10.1016/j.gendis.2021.08.010

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The potential regulatory role of BMP9 in inflammatory responses

更新时间：2022-11-09

- The potential regulatory role of BMP9 in inflammatory responses
- Genes & Diseases Vol. 9, Issue 6, (2022)
- 作者机构：
  
  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,PR China,610041
  2. Key Laboratory of Oral Diseases of Gansu Province, Northwest Minzu University, Key Laboratory of Stomatology of State Ethnic Affairs Commission, Northwest Minzu University,Gansu,Lanzhou,PR China,730030
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.08.010
  CLC：
- Published：2022，
  
  Published Online：1 November 2022，
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Tianzhu Song, Dingming Huang, Dongzhe Song. The potential regulatory role of BMP9 in inflammatory responses. [J]. Genes & Diseases 9(6).(2022)
DOI：

Tianzhu Song, Dingming Huang, Dongzhe Song. The potential regulatory role of BMP9 in inflammatory responses. [J]. Genes & Diseases 9(6).(2022) DOI： 10.1016/j.gendis.2021.08.010.

摘要

Abstract

Inflammation is a protective response of the body to pathogens and injury. Hence

it is particularly important to explore the pathogenesis and key regulatory factors of inflammation. BMP9 is a unique member of the BMP family

which is widely known for its strong osteogenic potential and insensitivity to the inhibition of BMP3. Recently

several studies have reported an underlying pivotal link between BMP9 and inflammation. What is clear

though not well understood

is that BMP9 plays a role in inflammation in a carefully choreographed manner in different contexts. In this review

we have summarized current studies focusing on BMP9 and inflammation in various tissues and the latest advances in BMP9 expression

signal transduction

and crystal structure to better understand the relationship between BMP9 and inflammation. In addition

we also briefly summarized the inflammatory characteristics of some TGF-β superfamily members to provide better insights and ideas for the study of BMP9 and inflammation.

关键词

Keywords

Bone morphogenetic protein 9 (BMP9)Crystal structureExpression profileInflammationTransforming growth factor-β (TGF-β)

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