Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

Wencheng Kong; Guang Yin; Sixin Zheng; Xinchun Liu; Akao Zhu; Panpan Yu; Jian Zhang; Yuqiang Shan; Rongchao Ying; Huicheng Jin

doi:10.1016/j.gendis.2021.07.006

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Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

更新时间：2022-08-11

- Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
- Genes & Diseases Vol. 9, Issue 5, (2022)
- 作者机构：
  
  Department of Gastroenterological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine,Zhejiang,Hangzhou,PR China,310006
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.07.006
  CLC：
- Published：2022，
  
  Published Online：1 September 2022，
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Wencheng Kong, Guang Yin, Sixin Zheng, et al. Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer. [J]. Genes & Diseases 9(5).(2022)
DOI：

Wencheng Kong, Guang Yin, Sixin Zheng, et al. Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer. [J]. Genes & Diseases 9(5).(2022) DOI： 10.1016/j.gendis.2021.07.006.

摘要

Abstract

Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors

leading to genomic stability

proliferation

survival

invasion

migration

metastasis

and drug resistance. In the present article

we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer

whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes

leading to the development of potential therapeutic strategies.

关键词

Keywords

ExpressionGastric cancerHOTAIR regulationRegulatory pathways

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