LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases

Fangqi Xia; Yaqi Wang; Mengzhen Xue; Leiqi Zhu; Dengke Jia; Yue Shi; Yan Gao; Luoying Li; Yuanyang Li; Silong Chen; Guangfu Xu; Ding Yuan; Chengfu Yuan

doi:10.1016/j.gendis.2021.07.003

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LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases

更新时间：2022-11-09

- LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases
- Genes & Diseases Vol. 9, Issue 6, (2022)
- 作者机构：
  
  1. College of Medical Science, China Three Gorges University,Hubei,Yichang,PR China,443002
  2. Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges,Hubei,Yichang,PR China,443002
  3. Hubei Key Laboratory of Tumour Microenvironment and Immunotherapy, China Three Gorges University,Hubei,Yichang,PR China,443002
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.07.003
  CLC：
- Published：2022，
  
  Published Online：1 November 2022，
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Fangqi Xia, Yaqi Wang, Mengzhen Xue, et al. LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases. [J]. Genes & Diseases 9(6).(2022)
DOI：

Fangqi Xia, Yaqi Wang, Mengzhen Xue, et al. LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases. [J]. Genes & Diseases 9(6).(2022) DOI： 10.1016/j.gendis.2021.07.003.

摘要

Abstract

Long non-coding RNAs (lncRNAs) exhibit a length more than 200 nucleotides and they are characterized by non-coding RNAs (ncRNA) not encoded into proteins. Over the past few years

the role and development of lncRNAs have aroused the rising attention of researchers. To be specific

KCNQ1OT1

the KCNQ1 opposite strand/antisense transcript 1

is clearly classified as a regulatory ncRNA. KCNQ1OT1 is capable of interacting with miRNAs

RNAs and proteins

thereby affecting gene expression and various cell functions (e.g.

cell proliferation

migration

epithelial–mesenchymal transition (EMT)

apoptosis

viability

autophagy and inflammation). KCNQ1OT1 is dysregulated in a wide range of human diseases (e.g.

cardiovascular disease

cancer

diabetes

osteoarthritis

osteoporosis and cataract)

and it is speculated to act as a therapeutic target for treating various human diseases. On the whole

this review aims to explore the biological functions

underlying mechanisms and pathogenic roles of KCNQ1OT1 in human diseases.

关键词

Keywords

Cell functionsHuman diseasesKCNQ1OT1Long non–coding RNARegulatory ncRNA

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