The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

Xiaokai Zhang; Yang Zhang; Aijun Sun; Junbo Ge

doi:10.1016/j.gendis.2021.04.001

您当前的位置：

首页 >

文章列表页 >

The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

更新时间：2022-06-24

- The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential
- Genes & Diseases Vol. 9, Issue 4, (2022)
- 作者机构：
  
  1. Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases,Shanghai,PR China,200032
  2. Institute of Biomedical Sciences, Fudan University,Shanghai,PR China,200032
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.04.001
  CLC：
- Published：2022，
  
  Published Online：1 July 2022，
扫描看全文
Xiaokai Zhang, Yang Zhang, Aijun Sun, et al. The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential. [J]. Genes & Diseases 9(4).(2022)
DOI：

Xiaokai Zhang, Yang Zhang, Aijun Sun, et al. The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential. [J]. Genes & Diseases 9(4).(2022) DOI： 10.1016/j.gendis.2021.04.001.

摘要

Abstract

Recently

cardiovascular diseases (CVDs) were identified as the leading cause of mortality

imposing a heavy burden on health care systems and the social economy. Nicotinamide adenine dinucleotide (NAD

)

as a pivotal co-substrate for a range of different enzymes

is involved in many signal transduction pathways activated in CVDs. Emerging evidence has shown that NAD

can exert remediating effects on CVDs by regulating metabolism

maintaining redox homeostasis and modulating the immune response. In fact

NAD

might delay ageing through sirtuin and non-sirtuin pathways and thus contribute to interventions for age-related diseases such as CVDs. Considering that robust clinical studies of NAD

are ongoing

we discuss current challenges and the future translational potential of NAD

based on existing studies and our understanding. Despite some remaining gaps in its clinical application

NAD

has been shown to have broad prospects and pan-effects

making it a suitable prophylactic drug for CVDs.

关键词

Keywords

AgeingCardiovascular diseaseMetabolismNicotinamide adenine dinucleotideSirtuin

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

De novo nucleotide biosynthetic pathway and cancer

Nicotinamide N-methyltransferase and liver diseases

The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

The emerging role of snoRNAs in human disease

The role of autophagy in regulating metabolism in the tumor microenvironment

Related Author

Huadong Pei

Yi Yao

Qibin Song

Pingfeng Zhang

Xu Ziwen

Yingge Li

Siqi Yang

Jie Chen

Related Institution

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,,.C.

Cancer Center, Renmin Hospital of Wuhan University

Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Department of Vascular & Intervention, Tenth Peoples' Hospital of Tongji University

⁰