Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease

Zhoupeng Li; Dehui Kong; Yongsheng Liu; Mingkai Li

doi:10.1016/j.gendis.2021.03.007

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Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease

更新时间：2022-06-24

- Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease
- Genes & Diseases Vol. 9, Issue 1, (2022)
- 作者机构：
  
  1. Department of Pharmacology & Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medical of the State Administration of Traditional Chinese Medicine, School of Pharmacy, The Fourth Military Medical University,Shanxi,Xi'an,PR China,710032
  2. School of Nursing, Army Medical University (Third Military Medical University),Chongqing,PR China,400038
  3. Precision Pharmacy & Drug Development Center, The Fourth Military Medical University,Shanxi,Xi'an,PR China,710032
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.03.007
  CLC：
- Published：2022，
  
  Published Online：1 January 2022，
扫描看全文
Zhoupeng Li, Dehui Kong, Yongsheng Liu, et al. Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease. [J]. Genes & Diseases 9(1).(2022)
DOI：

Zhoupeng Li, Dehui Kong, Yongsheng Liu, et al. Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease. [J]. Genes & Diseases 9(1).(2022) DOI： 10.1016/j.gendis.2021.03.007.

摘要

Abstract

Infections caused by viruses are one of the foremost causes of morbidity and mortality in the world. Although a number of antiviral drugs are currently used for treatment of various kinds of viral infection diseases

there is still no available therapeutic agent for most of the viruses in clinical practice. Coumarin is a chemical compound which is found naturally in a variety of plants

it can also be synthetically produced possessing diverse biological effects. More recently

reports have highlighted the potential role of coumarin derivatives as antiviral agents. This review outlines the advances in coumarin-based compounds against various viruses including human immunodeficiency virus

hepatitis virus

herpes simplex virus

Chikungunya virus and Enterovirus 71

as well as the structure activity relationship and the possible mechanism of action of the most potent coumarin derivatives.

关键词

Keywords

CoumarinHepatitis virusHuman immunodeficiency virusInfectionMolecular mechanism

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