Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration

Sheng Zhou; Song Chen; Yixuan Amy Pei; Ming Pei

doi:10.1016/j.gendis.2021.03.004

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Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration

更新时间：2022-06-24

- Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration
- Genes & Diseases Vol. 9, Issue 3, (2022)
- 作者机构：
  
  1. Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown,WV,USA,26506
  2. Department of Orthopaedics, The General Hospital of Western Theater Command,Sichuan,Chengdu,PR China,610083
  3. WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown,WV,USA,26506
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.03.004
  CLC：
- Published：2022，
  
  Published Online：1 May 2022，
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Sheng Zhou, Song Chen, Yixuan Amy Pei, et al. Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration. [J]. Genes & Diseases 9(3).(2022)
DOI：

Sheng Zhou, Song Chen, Yixuan Amy Pei, et al. Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration. [J]. Genes & Diseases 9(3).(2022) DOI： 10.1016/j.gendis.2021.03.004.

摘要

Abstract

Basement membrane proteins are known to guide cell structures

differentiation

and tissue repair. Although there is a wealth of knowledge on the functions of laminins

perlecan

and type IV collagen in maintaining tissue homeostasis

not much is known about nidogen. As a key molecule in the basement membrane

nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific differentiation. In this review

the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development; the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration

including but not limited to adipogenesis

angiogenesis

chondrogenesis

myogenesis

and neurogenesis. Furthermore

potential mechanisms underlying the role of nidogens in stem cell-based tissue regeneration are also discussed. This concise review is expected to facilitate our existing understanding and utilization of nidogen in tissue engineering and regeneration.

关键词

Keywords

AdiposeBasement membraneCartilageDifferentiationNerveNidogensVessel

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Related Institution

Jiangxi Province Key Laboratory of Animal Nutrition, Jiangxi Agricultural University

Stem Cell Biology and Therapy Laboratory, The Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics

Department of Pediatric Surgery, The Children’s Hospital of Chongqing Medical University

Department of Cell Biology, Army Medical University

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling

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