Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease

Liping Xiang; Yang Jiao; Yiling Qian; Yao Li; Fei Mao; Yan Lu

doi:10.1016/j.gendis.2021.02.008

您当前的位置：

首页 >

文章列表页 >

Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease

更新时间：2022-06-24

- Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease
- Genes & Diseases Vol. 9, Issue 1, (2022)
- 作者机构：
  
  1. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University,Shanghai,PR China,200032
  2. Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University,Shanghai,PR China,200032
  3. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine,Shanghai,PR China,200025
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.02.008
  CLC：
- Published：2022，
  
  Published Online：1 January 2022，
扫描看全文
Liping Xiang, Yang Jiao, Yiling Qian, et al. Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease. [J]. Genes & Diseases 9(1).(2022)
DOI：

Liping Xiang, Yang Jiao, Yiling Qian, et al. Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease. [J]. Genes & Diseases 9(1).(2022) DOI： 10.1016/j.gendis.2021.02.008.

摘要

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder worldwide. Murine models of NAFLD have been widely used to explore its pathogenesis. In this study

we performed a systematic evaluation of hepatic genome-wide mRNA expression by RNA-Sequencing using three mouse models of NAFLD: leptin receptor deficient db/db mice

high-fat high-sugar diet (HSHF)-induced obese mice

and dexamethasone (DEX)-induced NAFLD mice. As a result

we found both distinct and common pathways in the regulation of lipid metabolism from transcriptomes of three mouse models. Moreover

only a total of 12 differentially expressed genes (DEGs) were commonly detected among all three mouse groups

indicating very little overlap among all three models. Therefore

our results suggest that NAFLD is a heterogeneous disease with highly variable molecular mechanisms.

关键词

Keywords

DEGsMurine modelsNAFLDPathway analysisTranscriptome

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The journey towards physiology and pathology: Tracing the path of neuregulin 4

Hepatocyte nuclear factor 1A suppresses innate immune response by inducing degradation of TBK1 to inhibit steatohepatitis

Transcriptional control by HNF-1: Emerging evidence showing its role in lipid metabolism and lipid metabolism disorders

Recent advances in elucidating the genetics of common variable immunodeficiency

Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease

Related Author

Liang Guo

Wangjing Mu

Hongyang Luo

Jieying Zhu

Min Chen

Weilong Hong

Jinyong He

Cong Du

Related Institution

School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport

Guangdong Province Key Laboratory of Liver Disease Research, The Third Affiliated Hospital, Sun Yat-sen University

Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital, Sun Yat-sen University

Molecular Cancer Research Center School of Medicine, Sun Yat-sen University

Department of Emergency, The Third Affiliated Hospital, Sun Yat-sen University

⁰