Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy

Taobo Hu; Wei Hou; Enhua Xiao; Mengping Long

doi:10.1016/j.gendis.2021.02.005

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Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy

更新时间：2022-06-24

- Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy
- Genes & Diseases Vol. 9, Issue 3, (2022)
- 作者机构：
  
  1. Department of Breast Surgery, Peking University People's Hospital,Beijing,PR China,100044
  2. Department of Pathology, Peking University Cancer Hospital,Beijing,PR China,100142
  3. Department of Radiology, The Second Xiangya Hospital, Central South University,Hunan,Changsha,PR China,410011
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.02.005
  CLC：
- Published：2022，
  
  Published Online：1 May 2022，
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Taobo Hu, Wei Hou, Enhua Xiao, et al. Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy. [J]. Genes & Diseases 9(3).(2022)
DOI：

Taobo Hu, Wei Hou, Enhua Xiao, et al. Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy. [J]. Genes & Diseases 9(3).(2022) DOI： 10.1016/j.gendis.2021.02.005.

摘要

Abstract

Stress granules are non-membranous cytoplasmic foci induced by various stress conditions. It is a protective strategy used by cells to suppress overall translation during stress. In cancer cells

it was thought that the formation of stress granules could protect them from apoptosis and induces resistance towards anti-cancer drugs or radiation treatment which makes the stress granules a potential target for cancer treatment. However

most of our understanding of stress granules are still in the stage of molecular and cell biology

and a transitional gap for its actual effect on clinical settings remains. In this review

we summarize the mechanism and effect of stress granules formation in cancer and try to illuminate its potential applications in cancer therapy

using breast cancer as an example.

关键词

Keywords

ApoptosisBreast cancerDrug resistanceStress granulesTranslation initiation

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