Long noncoding RNAs (lncRNAs) in human lymphomas

Ali Gholami; Khosro Farhadi; Fatemeh Sayyadipour; Masoud Soleimani; Fakhredin Saba

doi:10.1016/j.gendis.2021.02.001

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Long noncoding RNAs (lncRNAs) in human lymphomas

更新时间：2022-06-24

- Long noncoding RNAs (lncRNAs) in human lymphomas
- Genes & Diseases Vol. 9, Issue 4, (2022)
- 作者机构：
  
  1. Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568,Iran,5420
  2. Department of Haematology, Tarbiat Modares University, Tehran 146899,Iran,5513
  3. Department of Medical Laboratory Science, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah 671568,Iran,5420
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.02.001
  CLC：
- Published：2022，
  
  Published Online：1 July 2022，
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Ali Gholami, Khosro Farhadi, Fatemeh Sayyadipour, et al. Long noncoding RNAs (lncRNAs) in human lymphomas. [J]. Genes & Diseases 9(4).(2022)
DOI：

Ali Gholami, Khosro Farhadi, Fatemeh Sayyadipour, et al. Long noncoding RNAs (lncRNAs) in human lymphomas. [J]. Genes & Diseases 9(4).(2022) DOI： 10.1016/j.gendis.2021.02.001.

摘要

Abstract

Lymphomas are a diverse group of haematologic malignancies

which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are non-coding RNAs

which have recently received significant attention as the main mediators of gene expression. In this review

we summarize the current knowledge on lncRNAs involved in lymphomas

their molecular functions

as well as their potential clinical value. Relevant literature was identified by a PubMed search of English language papers using the following terms: Lymphoma

LncRNA

leukemia

proliferation

apoptosis

and prognosis. LncRNAs are imperative for lymphoma carcinogenesis through affecting apoptosis

cell proliferation

invasion

and response to chemotherapy. The expression level of lncRNAs can affect chemotherapy-induced apoptosis. Taken together

lncRNA dysregulation in lymphoma cells is not only an epiphenomenon but also lncRNA transcription is critically related to the initiation and progression of lymphomas. Aberrant expression of lncRNAs can lead to the transformation of normal lymphocytes into lymphoma cells.

关键词

Keywords

ApoptosisLong non-coding RNALymphomaPrognosisProliferation

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