Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice

Min Luo; Qinghua Zeng; Kai Jiang; Yueyang Zhao; Zhimin Long; Yexiang Du; Kejian Wang; Guiqiong He

doi:10.1016/j.gendis.2021.01.007

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Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice

更新时间：2022-08-11

- Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice
- Genes & Diseases Vol. 9, Issue 5, (2022)
- 作者机构：
  
  1. Chongqing Key Laboratory of Neurobiology, Chongqing Medical University,Chongqing,PR China,400016
  2. Department of Pathology, Suining Municipal Hospital of TCM,Sichuan,Suining,PR China,629000
  3. Department of Anatomy, Chongqing Medical University,Chongqing,PR China,400016
  4. Department of Gastroenterology, Suining Central Hospital,Sichuan,Suining,PR China,629000
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.01.007
  CLC：
- Published：2022，
  
  Published Online：1 September 2022，
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Min Luo, Qinghua Zeng, Kai Jiang, et al. Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice. [J]. Genes & Diseases 9(5).(2022)
DOI：

Min Luo, Qinghua Zeng, Kai Jiang, et al. Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice. [J]. Genes & Diseases 9(5).(2022) DOI： 10.1016/j.gendis.2021.01.007.

摘要

Abstract

lterations in glucose metabolism occur in the brain in the early stage of Alzheimer's disease (AD)

and menopausal women have more severe metabolic dysfunction and are more prone to dementia than men. Although estrogen deficiency-induced changes in glucose metabolism have been previously studied in animal models

their molecular mechanisms in AD remain elusive. To investigate this issue

double transgenic (APP/PS1) female mice were subjected to bilateral ovariectomy at 3 months of age and were sacrificed 1 week

1 month and 3 months after surgery to simulate early

middle and late postmenopause

respectively. Our analysis demonstrated that estrogen deficiency exacerbates learning and memory deficits in this mouse model of postmenopause. Estrogen deficiency impairs the function of mitochondria in glucose metabolism. It is possible that the occurrence of AD is associated with the aberrant mitochondrial ERβ-mediated IGF-1/IGF-1R/GSK-3β signaling pathway. In this study

we established a potential mechanism for the increased risk of AD in postmenopausal women and proposed a therapeutic target for AD due to postmenopause.

关键词

Keywords

Alzheimer's diseaseEstrogen deficiencyGlucose metabolism disorderGSK-3βIGF-1Mitochondria

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