Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy

Qidi Jiang; Yiran Li; Quanli Wu; Li Huang; Jiasheng Xu; Qingfu Zeng

doi:10.1016/j.gendis.2021.01.001

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Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy

更新时间：2022-06-24

- Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy
- Genes & Diseases Vol. 9, Issue 3, (2022)
- 作者机构：
  
  1. Department of Biomedicine, Queen Mary University of London,Jiangxi,Nanchang,PR China,330006
  2. Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,PR China,330006
  3. School of Public Health, Nanchang University,Jiangxi,Nanchang,PR China,330001
  4. Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,PR China,330006
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.01.001
  CLC：
- Published：2022，
  
  Published Online：1 May 2022，
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Qidi Jiang, Yiran Li, Quanli Wu, et al. Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy. [J]. Genes & Diseases 9(3).(2022)
DOI：

Qidi Jiang, Yiran Li, Quanli Wu, et al. Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy. [J]. Genes & Diseases 9(3).(2022) DOI： 10.1016/j.gendis.2021.01.001.

摘要

Abstract

Ischemic stroke resulting from atherosclerosis (particularly in the carotid artery) is one of the major subtypes of stroke and has a high incidence of death. Disordered lipid homeostasis

lipid deposition

local macrophage infiltration

smooth muscle cell proliferation

and plaque rupture are the main pathological processes of atherosclerotic ischemic stroke. Hepatocytes

macrophages

endothelial cells and vascular smooth muscle cells are the main cell types participating in these processes. By inhibiting the expression of the target genes in these cells

microRNAs play a key role in regulating lipid disorders and atherosclerotic ischemic stroke. In this article

we listed the microRNAs implicated in the pathology of atherosclerotic ischemic stroke and aimed to explain their pro- or antiatherosclerotic roles. Our article provides an update on the potential diagnostic use of miRNAs for detecting growing plaques and impending clinical events. Finally

we provide a perspective on the therapeutic use of local microRNA delivery and discuss the challenges for this potential therapy.

关键词

Keywords

Atherosclerotic ischemic strokeECsMacrophagesmiRNAPlaque stabilityVSMCs

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