Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology

Hui Nie; Zhujun Liao; Yutong Wang; Jianhua Zhou; Xiaoyun He; Chunlin Ou

doi:10.1016/j.gendis.2020.12.004

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Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology

更新时间：2022-06-24

- Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology
- Genes & Diseases Vol. 8, Issue 6, (2021)
- 作者机构：
  
  1. Department of Pathology, Xiangya Hospital, Central South University,Hunan Province,Changsha,PR China,410008
  2. Department of Rheumatology and Immunology, Xiangya Hospital, Central South University,Hunan Province,Changsha,PR China,410008
  3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Hunan Province,Changsha,PR China,410008
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.12.004
  CLC：
- Published：2021，
  
  Published Online：1 November 2021，
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Hui Nie, Zhujun Liao, Yutong Wang, et al. Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology. [J]. Genes & Diseases 8(6).(2021)
DOI：

Hui Nie, Zhujun Liao, Yutong Wang, et al. Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology. [J]. Genes & Diseases 8(6).(2021) DOI： 10.1016/j.gendis.2020.12.004.

摘要

Abstract

Metastasis is a major challenge in the treatment of cancer. Exosomes are a class of small extracellular vesicles (EVs) that play critical roles in several human diseases

especially cancer

by transferring information (e.g.

DNA

RNA

and protein) via cell-to-cell communication. Numerous recent studies have shown that exosomal long non-coding RNAs (lncRNAs) play crucial regulatory roles in cancer metastasis in the tumor microenvironment by altering the expression of several key signaling pathways and molecules. Due to their specificity and sensitivity

exosomal lncRNAs have potential as novel tumor markers and therapeutic targets in the treatment of cancer metastasis. In this review

we aim to summarize the roles of exosomal lncRNAs in cancer metastasis

the mechanisms underlying their roles

and their potential clinical applications.

关键词

Keywords

Cancer metastasisExosomesExtracellular vesiclesLong noncoding RNATherapyTumor marker

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