Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

Feifei Pu; Fengxia Chen; Zhicai Zhang; Deyao Shi; Binlong Zhong; Xiao Lv; Andrew Blake Tucker; Jiaming Fan; Alexander J. Li; Kevin Qin; Daniel Hu; Connie Chen; Hao Wang; Fang He; Na Ni; Linjuan Huang; Qing Liu; William Wagstaff; Zengwu Shao

doi:10.1016/j.gendis.2020.11.019

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Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

更新时间：2022-06-24

- Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer
- Genes & Diseases Vol. 9, Issue 2, (2022)
- 作者机构：
  
  1. Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Hubei,Wuhan,PR China,430022
  2. Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University,Hubei,Wuhan,PR China,430071
  3. Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University,Hubei,Wuhan,PR China,430071
  4. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
  5. Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore,MD,USA,21205
  6. Ministry of Education Key Laboratory of Diagnostic Medicine, Department of Clinical Biochemistry, School of Laboratory Medicine, Chongqing Medical University,Chongqing,PR China,400016
  7. Departments of Nephrology, and Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University,Chongqing,PR China,400016
  8. Department of Spine Surgery, Second Xiangya Hospital, Central South University,Hunan,Changsha,PR China,410011
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.11.019
  CLC：
- Published：2022，
  
  Published Online：1 March 2022，
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Feifei Pu, Fengxia Chen, Zhicai Zhang, et al. Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer. [J]. Genes & Diseases 9(2).(2022)
DOI：

Feifei Pu, Fengxia Chen, Zhicai Zhang, et al. Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer. [J]. Genes & Diseases 9(2).(2022) DOI： 10.1016/j.gendis.2020.11.019.

摘要

Abstract

The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells. Anti-tumor drugs were developed to induce apoptosis

but some patient’s show apoptosis escape and chemotherapy resistance. Therefore

other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment. Ferroptosis is a newly discovered iron-dependent

non-apoptotic type of cell death that is highly negatively correlated with cancer development. Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis. This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment.

关键词

Keywords

CancerCancer therapyClinical applicationFerroptosisLipid peroxidationPathogenesis

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