The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine

Duguang Li; Xiaoxiao Fan; Yirun Li; Jing Yang; Hui Lin

doi:10.1016/j.gendis.2020.11.014

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The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine

更新时间：2022-06-24

- The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine
- Genes & Diseases Vol. 9, Issue 2, (2022)
- 作者机构：
  
  1. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,Zhejiang,Hangzhou,PR China,310058
  2. Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,Zhejiang,Hangzhou,PR China,310058
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.11.014
  CLC：
- Published：2022，
  
  Published Online：1 March 2022，
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Duguang Li, Xiaoxiao Fan, Yirun Li, et al. The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine. [J]. Genes & Diseases 9(2).(2022)
DOI：

Duguang Li, Xiaoxiao Fan, Yirun Li, et al. The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine. [J]. Genes & Diseases 9(2).(2022) DOI： 10.1016/j.gendis.2020.11.014.

摘要

Abstract

Hepatocellular carcinoma (HCC) is among the most aggressive and lethal diseases with poor prognosis

worldwide. However

the mechanisms underlying HCC have not been comprehensively elucidated. With the recent application of high-throughput sequencing techniques

a diverse catalogue of differentially expressed long non-coding RNAs (lncRNA) in cancer have been shown to participate in HCC. Rather than being “transcriptional noise

” they are emerging as important regulators of many biological processes

including chromatin remodelling

transcription

alternative splicing

translational and post-translational modification. Moreover

lncRNAs have dual effects in the development and progression of HCC

including oncogenic and tumour-suppressive roles. Collectively

recently data point to lncRNAs as novel diagnostic and prognostic biomarkers with satisfactory sensitivity and specificity

as well as being therapeutic targets for HCC patients. In this review

we highlight recent progress of the molecular patterns of lncRNAs and discuss their potential clinical application in human HCC.

关键词

Keywords

BiomarkerHepatocellular carcinomaLncRNAMolecular mechanismTherapy

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