Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants

Haiming Wang; Zifan Liu; Junjie Shao; Min Jiang; Xuechun Lu; Lejian Lin; Lin Wang; Qiang Xu; Haomin Zhang; Xin Li; Jingjing Zhou; Yundai Chen; Ran Zhang

doi:10.1016/j.gendis.2020.11.003

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Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants

更新时间：2022-06-24

- Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants
- Genes & Diseases Vol. 9, Issue 2, (2022)
- 作者机构：
  
  1. Department of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School,Beijing,PR China,100853
  2. The First Clinical Medical College of Inner Mongolia Medical University,Hohhot,PR China,010059
  3. Department of Hematology, The Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School,Beijing,PR China,100853
  4. Department of Health Services, The First Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School,Beijing,PR China,100853
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.11.003
  CLC：
- Published：2022，
  
  Published Online：1 March 2022，
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Haiming Wang, Zifan Liu, Junjie Shao, et al. Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants. [J]. Genes & Diseases 9(2).(2022)
DOI：

Haiming Wang, Zifan Liu, Junjie Shao, et al. Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants. [J]. Genes & Diseases 9(2).(2022) DOI： 10.1016/j.gendis.2020.11.003.

摘要

Abstract

The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies. Genome-wide association studies (GWASs) have identified a considerable number of common genetic variants that are associated with PCAD. Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms (SNPs). The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity. Some characteristic genetic variants have been identified in Chinese populations. Although translating this genetic knowledge into clinical applications is still challenging

these genetic variants can be used for CAD phenotype identification

genetic prediction and therapy. In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD. We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD.

关键词

Keywords

Genetic clinical applicationsGenetic variantsGenome-wide association studiesPremature coronary artery diseaseSingle-nucleotide polymorphisms

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