SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine

Xia Huang; Qiuman Chen; Wenping Luo; Mikhail Pakvasa; Yuxin Zhang; Liwen Zheng; Shuang Li; Zhuohui Yang; Huan Zeng; Fang Liang; Fugui Zhang; Daniel A. Hu; Kevin H. Qin; Eric J. Wang; David S. Qin; Russell R. Reid; Tong-Chuan He; Aravind Athiviraham; Hongmei Zhang

doi:10.1016/j.gendis.2020.10.003

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SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine

更新时间：2022-06-24

- SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine
- Genes & Diseases Vol. 9, Issue 1, (2022)
- 作者机构：
  
  1. Stomatological Hospital of Chongqing Medical University,Chongqing,PR China,401147
  2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing,PR China,401147
  3. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
  4. The Pritzker School of Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
  5. Department of Surgery, The University of Chicago Medical Center,IL,Chicago,USA,60637
  6. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing,PR China,401147
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.10.003
  CLC：
- Published：2022，
  
  Published Online：1 January 2022，
扫描看全文
Xia Huang, Qiuman Chen, Wenping Luo, et al. SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine. [J]. Genes & Diseases 9(1).(2022)
DOI：

Xia Huang, Qiuman Chen, Wenping Luo, et al. SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine. [J]. Genes & Diseases 9(1).(2022) DOI： 10.1016/j.gendis.2020.10.003.

摘要

Abstract

SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator

SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific

and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells

SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation

SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor

SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review

we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development

neurogenesis

tumorigenesis and regenerative medicine.

关键词

Keywords

Bone regenerationDevelopmentNeurogenesisSATB2Tumorigenesis

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