The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer

Xingxing Huang; Ting Pan; Lili Yan; Ting Jin; Ruonan Zhang; Bi Chen; Jiao Feng; Ting Duan; Yu Xiang; Mingming Zhang; Xiaying Chen; Zuyi Yang; Wenzheng Zhang; Xia Ding; Tian Xie; Xinbing Sui

doi:10.1016/j.gendis.2020.10.002

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The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer

更新时间：2022-06-24

- The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer
- Genes & Diseases Vol. 8, Issue 6, (2021)
- 作者机构：
  
  1. Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University,Zhejiang Province,Hangzhou,PR China,310015
  2. College of Pharmacy, School of Medicine, Hangzhou Normal University,Zhejiang Province,Hangzhou,PR China,311121
  3. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University,Zhejiang Province,Hangzhou,PR China,311121
  4. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine,Beijing,PR China,100029
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.10.002
  CLC：
- Published：2021，
  
  Published Online：1 November 2021，
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Xingxing Huang, Ting Pan, Lili Yan, et al. The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer. [J]. Genes & Diseases 8(6).(2021)
DOI：

Xingxing Huang, Ting Pan, Lili Yan, et al. The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer. [J]. Genes & Diseases 8(6).(2021) DOI： 10.1016/j.gendis.2020.10.002.

摘要

Abstract

umulating evidence suggests that chronic inflammation may play a critical role in various malignancies

including bladder cancer. This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment. Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of inflammatory molecules and signals. Recently

it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer

which can be mediated through the stimulation of chronic inflammation. In effect

the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder cancer. In other words

chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder cancer. Here

we provide a detailed and comprehensive account of the link between chronic inflammation

the microbiome and bladder cancer. Finally

we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment.

关键词

Keywords

Bladder cancerCarcinogenesisInflammatory microenvironmentPathogenesisProgressionUrinary microbiome

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