PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer

Jing-Fen Su; Anthony Concilla; Dian-zheng Zhang; Fang Zhao; Fang-Fang Shen; Hao Zhang; Fu-You Zhou

doi:10.1016/j.gendis.2020.09.006

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PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer

更新时间：2022-06-24

- PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer
- Genes & Diseases Vol. 8, Issue 5, (2021)
- 作者机构：
  
  1. Anyang Key Laboratory for Esophageal Cancer Research, Anyang Cancer Hospital, The Forth Affiliated Hospital of Henan University of Science and Technology,Henan Province,Anyang,PR China,455000
  2. Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia,PA,USA,19131
  3. Key Laboratory for Tumor Translational Medicine, The Third Affiliated Hospital, Xinxiang Medical University,Henan Province,Xinxiang,PR China,453000
  4. Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College,Guangdong Province,Guangzhou,PR China,510630
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.09.006
  CLC：
- Published：2021，
  
  Published Online：1 September 2021，
扫描看全文
Jing-Fen Su, Anthony Concilla, Dian-zheng Zhang, et al. PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer. [J]. Genes & Diseases 8(5).(2021)
DOI：

Jing-Fen Su, Anthony Concilla, Dian-zheng Zhang, et al. PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer. [J]. Genes & Diseases 8(5).(2021) DOI： 10.1016/j.gendis.2020.09.006.

摘要

Abstract

PIWI-interacting RNA (piRNAs)

once thought to be mainly functioning in germlines

are now known to play an essential role in somatic and cancerous tissues. Ping-pong cycle initiation and mitochondria-based phased production constitute the core of the piRNA biogenesis and these two processes are well conserved in mammals

including humans. By being involved in DNA methylation

histone marker deposition

mRNA degradation

and protein modification

piRNAs also contribute to carcinogenesis partly due to oncogenic stress-induced piRNA dysregulation. Also

piRNAs play important roles in cancer stemness

drug resistance

and tumor immunology. Results from liquid biopsy analysis of piRNA can be used in both cancer diagnoses and cancer prognoses. A combination of targeting piRNA with other therapeutic strategies could be groundbreaking cancer treatment.

关键词

Keywords

CarcinogenesisClinical utilityMitochondria-based phased productionPing-pong cyclePiwi-interacting RNAs

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