The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses

Yi Pan; Qingshang Li; Zhijun Cao; Shuliang Zhao

doi:10.1016/j.gendis.2020.08.010

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The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses

更新时间：2022-06-24

- The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses
- Genes & Diseases Vol. 8, Issue 6, (2021)
- 作者机构：
  
  Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai,PR China,200030
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.08.010
  CLC：
- Published：2021，
  
  Published Online：1 November 2021，
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Yi Pan, Qingshang Li, Zhijun Cao, et al. The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses. [J]. Genes & Diseases 8(6).(2021)
DOI：

Yi Pan, Qingshang Li, Zhijun Cao, et al. The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses. [J]. Genes & Diseases 8(6).(2021) DOI： 10.1016/j.gendis.2020.08.010.

摘要

Abstract

Gastric cancer (GC) is one of the most common malignancies

with an ever-increasing incidence and high mortality rate. Chromobox4 (CBX4)

also named hPC2

is a small ubiquitin-related modifier (SUMO) E3 ligase. Previous studies have found that high CBX4 expression is associated with tumor size

pathologic differentiation and decreased patient survival in hepatocellular carcinoma (HCC). However

the expression and prognostic value of CBX4 in GC have not been clarified. In our study

ONCOMINE

UALCAN

Kaplan-Meier Plotter

cBioPortal

DAVID 6.8 and TIMER were utilized. RT-PCR

immunohistochemistry (IHC)

Western blot

CCK-8 assay

cell apoptosis assay

cell cycle assay were used to further verify in GC tissue samples or cell line. The transcriptional and protein level of CBX4 in GC tissues was found significantly elevated and a significant association between the expression of CBX4 and clinicopathological parameters was found in GC patients. Low expression of CBX4 in GC patients were correlated with a significantly improved prognosis. The functions of CBX4 are primarily related to the stem cell pluripotency signaling pathway

Hippo signaling pathway

HTLV-I infection

Notch signaling pathway

and N-glycan biosynthesis. Our results may provide novel insights for the selection of therapeutic targets and prognostic biomarkers for GC.

关键词

Keywords

Bioinformatics analysisChromobox4 (CBX4)Gastric cancerPrognostic biomarkerTherapeutic target

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