Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration

Min Xu; Yu-Meng Wang; Wan-Qing Li; Cheng-Long Huang; Jun Li; Wen-Hua Xie; Hong-Xiang Zeng; Lin-Fen Tao; Xi Li

doi:10.1016/j.gendis.2020.08.009

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Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration

更新时间：2022-06-24

- Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration
- Genes & Diseases Vol. 9, Issue 2, (2022)
- 作者机构：
  
  Biology Science Institutes, Chongqing Medical University,Chongqing,PR China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.08.009
  CLC：
- Published：2022，
  
  Published Online：1 March 2022，
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Min Xu, Yu-Meng Wang, Wan-Qing Li, et al. Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration. [J]. Genes & Diseases 9(2).(2022)
DOI：

Min Xu, Yu-Meng Wang, Wan-Qing Li, et al. Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration. [J]. Genes & Diseases 9(2).(2022) DOI： 10.1016/j.gendis.2020.08.009.

摘要

Abstract

Obesity-induced inflammation

characterized by augmented infiltration and altered balance of macrophages

is a critical component of systemic insulin resistance. Chemokine-chemokine receptor system plays a vital role in the macrophages accumulation. CC-Chemokine Receptor-like 2 (Ccrl2) is one of the receptors of Chemerin

which is a member of atypical chemokine receptors (ACKR) family

reported taking part in host immune responses and inflammation-related conditions. In our study

we found

ccrl2

expression significantly elevated in visceral adipose tissue (VAT) of high fat diet (HFD) induced obese mice and

ob/ob

mice. Systemic deletion of

Ccrl2

gene aggravated HFD induced obesity and insulin resistance and

ccrl2

−/−

mice showed aggravated VAT inflammation and increased M1/M2 macrophages ratio

which is due to the increase of macrophages chemotaxis in Ccrl2 deficiency mice. Cumulatively

these results indicate that Ccrl2 has a critical function in obesity and obesity-induced insulin resistance via mediating macrophages chemotaxis.

关键词

Keywords

Ccrl2InflammationInsulin resistanceMacrophagesObesity

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