Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma

Zhenyu Ye; Yecheng Li; Jiaming Xie; Zhenyu Feng; Xiaodong Yang; Yong Wu; Yuwei Pu; Jiawei Gao; Xiangrong Xu; Zhaobi Zhu; Wei Li; Wei Chen; Chungen Xing

doi:10.1016/j.gendis.2020.04.008

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Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma

更新时间：2022-06-24

- Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma
- Genes & Diseases Vol. 8, Issue 4, (2021)
- 作者机构：
  
  Department of General Surgery, The Second Affiliated Hospital of Soochow University,Jiangsu Province,Suzhou,PR China,215004
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.04.008
  CLC：
- Published：2021，
  
  Published Online：1 July 2021，
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Zhenyu Ye, Yecheng Li, Jiaming Xie, et al. Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma. [J]. Genes & Diseases 8(4).(2021)
DOI：

Zhenyu Ye, Yecheng Li, Jiaming Xie, et al. Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma. [J]. Genes & Diseases 8(4).(2021) DOI： 10.1016/j.gendis.2020.04.008.

摘要

Abstract

Colorectal carcinoma (CRC) is one of the most common cancers

and is associated with a poor clinical outcome. The key genes and potential prognostic markers in colorectal carcinoma remain to be identified and explored for clinical application. DNA expression/methylation profiles were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed/methylated genes (DEGs and DEMs). A total of 255 genes and 372 genes were identified as being up-regulated and down-regulated

respectively

in GSE113513

GSE81558

and GSE89076. There were a total of 3350 hypermethylated genes and 443 hypomethylated genes identified in GSE48684. Twenty genes were found to be hypermethylated as well as down-regulated

and a functional enrichment analysis revealed that these genes were mainly involved in cancer-related pathways. Among these 20 genes

GPM6A

HAND2 and C2orf40 were related to poor outcomes in cancer patients based on a survival analysis. Concurrent decreases of GPM6A

HAND2 and C2orf40 protein expression were observed in highly-differentiated colorectal carcinoma tissues

and higher expression levels were found in undifferentiated or minimally-differentiated colorectal carcinoma tissues. In conclusion

20 genes were found to be downregulated and hypermethylated in CRC

among which GPM6A

HAND2 and C2orf40 were explored for their potential prognostic value.

关键词

Keywords

BioinformaticsC2orf40Colorectal carcinomaGPM6AHAND2Hypermethylation

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