Genetic variation in the chemokine receptor 5 gene and course of HIV infection; review on genetics and immunological aspect

M.K. Verma; S. Shakya

doi:10.1016/j.gendis.2020.04.007

您当前的位置：

首页 >

文章列表页 >

Genetic variation in the chemokine receptor 5 gene and course of HIV infection; review on genetics and immunological aspect

更新时间：2022-06-24

- Genetic variation in the chemokine receptor 5 gene and course of HIV infection; review on genetics and immunological aspect
- Genes & Diseases Vol. 8, Issue 4, (2021)
- 作者机构：
  
  1. Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh,India,522510
  2. Indian Institute of Technology Indore, Indore, Madhya Pradesh,India,453552
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.04.007
  CLC：
- Published：2021，
  
  Published Online：1 July 2021，
扫描看全文
M.K. Verma, S. Shakya. Genetic variation in the chemokine receptor 5 gene and course of HIV infection; review on genetics and immunological aspect. [J]. Genes & Diseases 8(4).(2021)
DOI：

M.K. Verma, S. Shakya. Genetic variation in the chemokine receptor 5 gene and course of HIV infection; review on genetics and immunological aspect. [J]. Genes & Diseases 8(4).(2021) DOI： 10.1016/j.gendis.2020.04.007.

摘要

Abstract

Chemokines are small protein molecules associated with various physiological events precisely in immune modulation via chemokine receptors. The chemokine receptors are G-protein coupled receptors express mainly on the cell surface of immune cells. Retroviruses

including HIV in the early stage of infection

primarily target chemokines receptors and get internalized easily into immune cells; T cell and escape from immune surveillance. HIV glycoprotein selectively develops an affinity for the extracellular domain of chemokines receptors and allows the pathogen to internalize via CCR-5. Now

CCR-5 remains a crucial signaling pathway that can be translated into the therapeutic target by changing the receptor protein environment. Many populations have a mutation in coding and promoter regions of CCR-5

tuning a resistance for HIV infection. Natively

there are several mechanisms where the human genome remains in the dynamic state by changing its composition and acquiring variations. Single nucleotide polymorphism is spontaneous phenomenon responsible for precise and point mutation at the genome. Several studies have demonstrated that European and African American populations are enriched in significant CCR5 promoter SNP (CCR5Δ32) in the coding and promoter region as well. Now

such SNP can be an early-stage biomarker in studying HIV and other similar infections. Here

in this study

we have elucidated the role of SNP (both the promoter and coding region) and the fate of HIV infections. We also empathized with the genetics of such SNPs

mostly frequency and its immunological impact.

关键词

Keywords

Acquired immunodeficiency syndromeChemokine and chemokine receptorsHuman immune deficiency virusesSingle nucleotide polymorphism

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

HLA-G and single nucleotide polymorphism (SNP) associations with cancer in African populations: Implications in personal medicine

Related Author

Ismael Chatita Adolf

Amany Almars

Nazima Dharsee

Teddy Mselle

Gokce Akan

Irene Jeremiah Nguma

Abdolrahman S. Nateri

Fatmahan Atalar

Related Institution

Mbeya College of Health and Allied Sciences, University of Dar es Salaam,, P.O Box

Cancer Genetics & Stem Cell Group, BioDiscovery Institute, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham

Ocean Road Cancer Institute, Department of Oncology, Dar es Salaam,.O Box

Muhimbili University of Health and Allied Sciences, MUHAS Genetic Laboratory, Department of Biochemistry, Dar es Salaam,.O Box

Clinical Oncology Department, Mbeya Zonal Referral Hospital (MZRH),P.O Box

⁰