Notch signaling: Its essential roles in bone and craniofacial development

Mikhail Pakvasa; Pranav Haravu; Michael Boachie-Mensah; Alonzo Jones; Elam Coalson; Junyi Liao; Zongyue Zeng; Di Wu; Kevin Qin; Xiaoxing Wu; Huaxiu Luo; Jing Zhang; Meng Zhang; Fang He; Yukun Mao; Yongtao Zhang; Changchun Niu; Meng Wu; Russell R. Reid

doi:10.1016/j.gendis.2020.04.006

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Notch signaling: Its essential roles in bone and craniofacial development

更新时间：2022-06-24

- Notch signaling: Its essential roles in bone and craniofacial development
- Genes & Diseases Vol. 8, Issue 1, (2021)
- 作者机构：
  
  1. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
  2. Pritzker School of Medicine, University of Chicago,IL,Chicago,USA,60637
  3. Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medical Center,IL,Chicago,USA,60637
  4. Departments of Orthopaedic Surgery, Gastrointestinal Surgery, Obstetrics and Gynecology, and Nephrology, The First Affiliated Hospital of Chongqing Medical University,Chongqing,PR China,400016
  5. Ministry of Education Key Laboratory of Diagnostic Medicine, and School of Laboratory and Diagnostic Medicine, Chongqing Medical University,Chongqing,PR China,400016
  6. Department of Burn and Plastic Surgery, West China Hospital of Sichuan University,Sichuan,Chengdu,PR China,610041
  7. Department of Orthopaedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine,Guangdong,Guangzhou,PR China,510405
  8. Departments of Orthopaedic Surgery and Neurosurgery, The Affiliated Zhongnan Hospital of Wuhan University,Hubei,Wuhan,PR China,430072
  9. Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University,Shandong,Qingdao,PR China,266061
  10. Department of Laboratory Diagnostic Medicine, Chongqing General Hospital,Chongqing,PR China,400021
  11. Institute of Bone and Joint Research, and the Department of Orthopaedic Surgery, The Second Hospitals of Lanzhou University,Gansu,Lanzhou,PR China,730030
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.04.006
  CLC：
- Published：2021，
  
  Published Online：1 January 2021，
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Mikhail Pakvasa, Pranav Haravu, Michael Boachie-Mensah, et al. Notch signaling: Its essential roles in bone and craniofacial development. [J]. Genes & Diseases 8(1).(2021)
DOI：

Mikhail Pakvasa, Pranav Haravu, Michael Boachie-Mensah, et al. Notch signaling: Its essential roles in bone and craniofacial development. [J]. Genes & Diseases 8(1).(2021) DOI： 10.1016/j.gendis.2020.04.006.

摘要

Abstract

Notch is a cell–cell signaling pathway that is involved in a host of activities including development

oncogenesis

skeletal homeostasis

and much more. More specifically

recent research has demonstrated the importance of Notch signaling in osteogenic differentiation

bone healing

and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton

skull

and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system

and what importance it may play in the future.

关键词

Keywords

Alagille syndromeBoneCraniofacial developmentCraniosynostosisNotchOncogenesisOsteogenesisSpondylocostal dysosotosis

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