The clinical and immunological features of pediatric COVID-19 patients in China

Juan Chen; Zhen-Zhen Zhang; Yao-Kai Chen; Quan-Xin Long; Wen-Guang Tian; Hai-Jun Deng; Jie-Li Hu; Xian-Xiang Zhang; Pu-Liao; Jiang-Lin Xiang; Dao-Xin Wang; Peng Hu; Fa-Chun Zhou; Zhi-Jie Li; Hong-Mei Xu; Xue-Fei Cai; De-Qiang Wang; Yuan Hu; Ai-Long Huang

doi:10.1016/j.gendis.2020.03.008

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The clinical and immunological features of pediatric COVID-19 patients in China

更新时间：2022-06-24

- The clinical and immunological features of pediatric COVID-19 patients in China
- Genes & Diseases Vol. 7, Issue 4, (2020)
- 作者机构：
  
  1. The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University,Chongqing,China
  2. Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders, The Children's Hospital of Chongqing Medical University,Chongqing,China
  3. Division of Infectious Diseases, Chonqging Public Health Medical Center,Chongqing,China
  4. Department of Infectious Diseases, Yongchuan Hospital Affiliated to Chongqing Medical University,Chongqing,China
  5. Department of Endocrinology, Chongqing Three Gorges Central Hospital,Chongqing,China
  6. Department of Clinical Laboratory, Chongqing People's Hospital,Chongqing,China
  7. Department of Infectious Diseases, Chongqing Three Gorges Central Hospital,Chongqing,China
  8. Department of Respiration, The First Affiliated Hospital, Chongqing Medical University,Chongqing,China
  9. Department of Emergency, The First Affiliated Hospital, Chongqing Medical University,Chongqing,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.03.008
  CLC：
- Published：2020，
  
  Published Online：1 December 2020，
扫描看全文
Juan Chen, Zhen-Zhen Zhang, Yao-Kai Chen, et al. The clinical and immunological features of pediatric COVID-19 patients in China. [J]. Genes & Diseases 7(4).(2020)
DOI：

Juan Chen, Zhen-Zhen Zhang, Yao-Kai Chen, et al. The clinical and immunological features of pediatric COVID-19 patients in China. [J]. Genes & Diseases 7(4).(2020) DOI： 10.1016/j.gendis.2020.03.008.

摘要

Abstract

In December 2019

the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan

China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17)

and six of the patients were male. The average incubation period was 8 days. Clinically

cough (9/12

75%) and fever (7/12

58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile

children had higher amount of total T cell

CD8+ T cell and B cell but lower CRP levels than adults (

0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3–4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level

which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.

关键词

Keywords

Clinical featuresCOVID-19ImmunePaediatricsSARS-Cov-2

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