Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Junhui Zhang; Jian Han; Lingfei Li; Qiong Zhang; Yanhai Feng; Youzhao Jiang; Fang Deng; Yuping Zhang; Qinan Wu; Bing Chen; Jiongyu Hu

doi:10.1016/j.gendis.2020.03.006

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Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

更新时间：2022-06-24

- Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases
- Genes & Diseases Vol. 8, Issue 3, (2021)
- 作者机构：
  
  1. Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University),Chongqing,PR China,400038
  2. State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University),Chongqing,PR China,400038
  3. Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University),Chongqing,PR China,400038
  4. Department of Obstetrics and Gynecology, Daping Hospital, Third Military Medical University (Army Medical University),Chongqing,PR China,400042
  5. Department of Dermatology, Daping Hospital, Third Military Medical University (Army Medical University),Chongqing,PR China,400042
  6. Department of Endocrinology, People's Hospital of Banan District,Chongqing,PR China,401320
  7. Department of Endocrinology, Chongqing Cancer Hospital (Chongqing University Cancer Hospital),Chongqing,PR China,40030
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.03.006
  CLC：
- Published：2021，
  
  Published Online：1 May 2021，
扫描看全文
Junhui Zhang, Jian Han, Lingfei Li, et al. Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases. [J]. Genes & Diseases 8(3).(2021)
DOI：

Junhui Zhang, Jian Han, Lingfei Li, et al. Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases. [J]. Genes & Diseases 8(3).(2021) DOI： 10.1016/j.gendis.2020.03.006.

摘要

Abstract

Inwardly rectifying potassium (Kir) channels make it easier for K

to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by

KCNJ16

) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by

KCNJ10

) or Kir4.2 (encoded by

KCNJ15

). In most cases

homomeric Kir5.1 is non-functional

while heteromeric Kir5.1 on the cell membrane contributes to the inward flow of K

ions

which can be regulated by intracellular pH and a variety of signaling mechanisms. In the form of a heterotetramer

Kir5.1 regulates Kir4.1/4.2 activity and is involved in the maintenance of nephron function. Actually

homomeric Kir5.1 may also play a very important role in diseases

including in the ventilatory response to hypoxia and hypercapnia

hearing impairment

cardiovascular disease and cancer. With an increase in the number of studies into the roles of Kir channels

researchers are paying more attention to the pathophysiological functions of Kir5.1. This minireview provides an overview regarding these Kir5.1 roles.

关键词

Keywords

CancerCardiovascular diseaseCochleaKir5.1 heterotetramerVentilatory response

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